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Tchem
MMP9
Matrix metalloproteinase-9

Protein Summary
Description
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a rol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372330
  • ENSP00000361405
  • ENSG00000100985

Symbol
  • CLG4B
  • GELB
  • CLG4B
  • MMP-9
  • MANDP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
1
protein domain
1
gene perturbation
0.99
biological process
0.97


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11633.26   (req: < 5)
Gene RIFs: 2467   (req: <= 3)
Antibodies: 1827   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11633.26   (req: >= 5)
Gene RIFs: 2467   (req: > 3)
Antibodies: 1827   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1830
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 9
VGNC:6191
458294
Macaque
matrix metallopeptidase 9
708084
Mouse
MGI:97011
17395
Rat
RGD:621320
81687
Dog
matrix metallopeptidase 9
VGNC:43290
403885
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 9
Macaque
matrix metallopeptidase 9
Mouse
Rat
Dog
matrix metallopeptidase 9
Protein Structure (26 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P14780-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 26
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (72)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Axon guidance
Reactome
Collagen degradation
Reactome
Collagen formation
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
Axon guidance
Collagen degradation
Collagen formation
Gene Ontology Terms (40)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (657)
1 – 10 of 657
COL12A1
Tbio
Novelty: 0.0239421
p_int: 0.999999898
p_ni: 9.5e-8
p_wrong: 7e-9
Score: 0.473
Data Source: BioPlex,STRINGDB
TIMP1
Tbio
Family: Enzyme
Novelty: 0.00020986
p_int: 0.999998964
p_ni: 0.000001
p_wrong: 3.6e-8
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
COL2A1
Tbio
Novelty: 0.0011102
p_int: 0.999998423
p_ni: 0.000001576
Score: 0.506
Data Source: BioPlex,STRINGDB
COL14A1
Tbio
Novelty: 0.01760399
p_int: 0.999996994
p_ni: 0.000003006
Score: 0.928
Data Source: BioPlex,STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
p_int: 0.99998814
p_ni: 0.000011821
p_wrong: 3.9e-8
Score: 0.421
Data Source: BioPlex,STRINGDB
COL6A2
Tbio
Novelty: 0.01275082
p_int: 0.99996002
p_ni: 0.00003998
Score: 0.292
Data Source: BioPlex,STRINGDB
COL4A1
Tbio
Novelty: 0.00358049
p_int: 0.999954443
p_ni: 0.000007532
p_wrong: 0.000038024
Score: 0.583
Data Source: BioPlex,STRINGDB
FN1
Tchem
Novelty: 0.00003647
p_int: 0.999634344
p_ni: 0.000365656
Score: 0.599
Data Source: BioPlex,STRINGDB
COL4A2
Tbio
Novelty: 0.00782053
p_int: 0.999269461
p_ni: 0.000730539
Score: 0.538
Data Source: BioPlex,STRINGDB
COL6A1
Tbio
Novelty: 0.00644855
p_int: 0.999005905
p_ni: 0.000994095
Score: 0.419
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  11633.26

PubMed score by year
PubTator Score  9137.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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