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Tbio
RAPGEF1
Rap guanine nucleotide exchange factor 1

Protein Summary
Description
Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372189
  • ENSP00000361263
  • ENSG00000107263
  • ENST00000372190
  • ENSP00000361264
  • ENST00000372195
  • ENSP00000361269

Symbol
  • GRF2
  • C3G
  • GRF2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
biological process
0.93
transcription factor perturbation
0.84
transcription factor
0.74
transcription factor binding site profile
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 305.18   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 305.18   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
1
1
48.9
1
1
0
1.1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
48.9
0
1.1
17.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rap guanine nucleotide exchange factor 1
VGNC:4845
464812
Macaque
Rap guanine nucleotide exchange factor 1
715272
Mouse
MGI:104580
107746
Rat
RGD:619793
63881
Dog
Rap guanine nucleotide exchange factor 1
VGNC:45346
491286
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rap guanine nucleotide exchange factor 1
Macaque
Rap guanine nucleotide exchange factor 1
Mouse
Rat
Dog
Rap guanine nucleotide exchange factor 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13905-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (54)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream signal transduction
Reactome
Erythropoietin activates RAS
Reactome
Frs2-mediated activation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Downstream signal transduction
Erythropoietin activates RAS
Frs2-mediated activation
Immune System
Protein-Protein Interactions (129)
1 – 10 of 129
CRK
Tbio
Novelty: 0.00238512
Score: 0.998
Data Source: Reactome,STRINGDB
CRKL
Tbio
Novelty: 0.0051181
Score: 0.997
Data Source: Reactome,STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
Score: 0.986
Data Source: Reactome,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.98
Data Source: STRINGDB
BCAR1
Tbio
Novelty: 0.00329214
Score: 0.979
Data Source: Reactome,STRINGDB
RAP1B
Tbio
Family: Enzyme
Novelty: 0.00627538
Score: 0.973
Data Source: Reactome,STRINGDB
CBL
Tbio
Family: Enzyme
Novelty: 0.00114929
Score: 0.969
Data Source: Reactome,STRINGDB
PTK2
Tclin
Family: Kinase
Novelty: 0.00066622
Score: 0.963
Data Source: STRINGDB
RHOQ
Tbio
Family: Enzyme
Novelty: 0.00562425
Score: 0.962
Data Source: STRINGDB
LRPAP1
Tbio
Novelty: 0.00214194
Score: 0.956
Data Source: STRINGDB
Publication Statistics
PubMed Score  305.18

PubMed score by year
PubTator Score  168.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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