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Tbio
KCNE5
Potassium voltage-gated channel subfamily E regulatory beta subunit 5

Protein Summary
Description
Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. This gene encodes a member of a family of single pass transmembrane domain proteins that function as ancillary subunits to voltage-gated potassium channels. Members of this family affect diverse processes in potassium channel regulation, including ion selectivity, voltage dependence, and anterograde recycling from the plasma membrane. Variants of this gene are associated with idiopathic ventricular fibrillation and Brugada syndrome. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372101
  • ENSP00000361173
  • ENSG00000176076

Symbol
  • AMMECR2
  • KCNE1L
  • KCNE1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
biological process
0.63
gene perturbation
0.6
cell type or tissue
0.58
disease
0.52


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.38   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.38   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily E regulatory subunit 5
VGNC:12434
740401
Mouse
MGI:1913490
66240
Rat
RGD:1583501
681190
Dog
potassium voltage-gated channel subfamily E regulatory subunit 5
VGNC:42243
610432
Cow
potassium voltage-gated channel subfamily E regulatory subunit 5
VGNC:30440
508071
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily E regulatory subunit 5
Mouse
Rat
Dog
potassium voltage-gated channel subfamily E regulatory subunit 5
Cow
potassium voltage-gated channel subfamily E regulatory subunit 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UJ90-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 2 - plateau phase
Reactome
Phase 3 - rapid repolarisation
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 2 - plateau phase
Phase 3 - rapid repolarisation
Protein-Protein Interactions (60)
1 – 10 of 60
KCNQ1
Tclin
Family: IC
Novelty: 0.0008956
Score: 0.969
Data Source: STRINGDB
KCNH2
Tclin
Family: IC
Novelty: 0.00041611
Score: 0.961
Data Source: STRINGDB
AKAP9
Tbio
Family: Enzyme
Novelty: 0.0106532
Score: 0.951
Data Source: STRINGDB
KCNE3
Tbio
Family: IC
Novelty: 0.01541806
Score: 0.843
Data Source: STRINGDB
AMMECR1
Tbio
Novelty: 0.12679247
Score: 0.807
Data Source: STRINGDB
KCNE4
Tbio
Family: IC
Novelty: 0.04524673
Score: 0.802
Data Source: STRINGDB
ACSL4
Tbio
Family: Enzyme
Novelty: 0.0072645
Score: 0.8
Data Source: STRINGDB
PGRMC1
Tbio
Novelty: 0.00364386
Score: 0.771
Data Source: STRINGDB
KCNE1
Tbio
Family: IC
Novelty: 0.0015463
Score: 0.75
Data Source: STRINGDB
KCNE2
Tbio
Family: IC
Novelty: 0.0073267
Score: 0.749
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.38

PubMed score by year
PubTator Score  13.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer