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Tbio
AMOT
Angiomotin

Protein Summary
Description
Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304758
  • ENSP00000305557
  • ENSG00000126016
  • ENST00000371959
  • ENSP00000361027
  • ENST00000524145
  • ENSP00000429013

Symbol
  • KIAA1071
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.81
PubMedID
0.77
transcription factor perturbation
0.74
histone modification site profile
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.26   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 399   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.26   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 399   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
angiomotin
VGNC:1492
465814
Macaque
angiomotin
707701
Mouse
MGI:108440
27494
Rat
RGD:1564027
300289
Dog
angiomotin
VGNC:37835
481022
Species
Name
OMA
EggNOG
Inparanoid
Chimp
angiomotin
Macaque
angiomotin
Mouse
Rat
Dog
angiomotin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q4VCS5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (60)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Hippo
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Hippo
Gene Ontology Terms (36)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (88)
1 – 10 of 88
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
p_int: 0.991228852
p_ni: 0.008771148
Score: 0.313
Data Source: BioPlex,STRINGDB
MPP5
Tbio
Novelty: 0.01707773
p_int: 0.990665455
p_ni: 0.009334545
Score: 0.975
Data Source: BioPlex,STRINGDB
RAB3IL1
Tbio
Novelty: 0.0167537
p_int: 0.979502277
p_ni: 0.020497723
Score: 0.188
Data Source: BioPlex,STRINGDB
MLH1
Tbio
Novelty: 0.00034212
p_int: 0.945998977
p_ni: 0.054001023
Data Source: BioPlex
WWP2
Tbio
Family: Enzyme
Novelty: 0.01935799
p_int: 0.923091714
p_ni: 0.076908286
Score: 0.253
Data Source: BioPlex,STRINGDB
MED4
Tbio
Family: Enzyme
Novelty: 0.01200585
p_int: 0.853992256
p_ni: 0.146007744
Data Source: BioPlex
RNF166
Tdark
Novelty: 0.71460884
p_int: 0.848522817
p_ni: 0.151477183
Score: 0.181
Data Source: BioPlex,STRINGDB
MAGEA4
Tbio
Novelty: 0.00949096
p_int: 0.84660737
p_ni: 0.15339263
Score: 0.189
Data Source: BioPlex,STRINGDB
YAP1
Tbio
Novelty: 0.00124225
Score: 0.976
Data Source: Reactome,STRINGDB
WWTR1
Tbio
Novelty: 0.00431186
Score: 0.955
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  100.26

PubMed score by year
PubTator Score  25.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer