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Tchem
PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Protein Summary
Description
Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371953
  • ENSP00000361021
  • ENSG00000171862

Symbol
  • MMAC1
  • TEP1
  • BZS
  • DEC
  • CWS1
  • GLM2
  • MHAM
  • TEP1
  • MMAC1
  • PTEN1
  • 10q23del
  • PTENbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
disease perturbation
1
kinase
1
kinase perturbation
1


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7893.93   (req: < 5)
Gene RIFs: 1886   (req: <= 3)
Antibodies: 1026   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7893.93   (req: >= 5)
Gene RIFs: 1886   (req: > 3)
Antibodies: 1026   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 120
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
P6949
chemical structure image
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
4
4
91.5
neutrophil count
2
2
2
84.2
2
2
1
1
82.4
myeloid white cell count
1
1
1
78.3
basophil count
2
1
2
74.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
91.5
neutrophil count
2
84.2
1
1
82.4
myeloid white cell count
1
78.3
basophil count
2
74.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatase and tensin homolog
VGNC:12442
466142
Macaque
phosphatase and tensin homolog
705121
Mouse
MGI:109583
19211
Rat
RGD:61995
50557
Dog
phosphatase and tensin homolog
VGNC:45138
403832
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatase and tensin homolog
Macaque
phosphatase and tensin homolog
Mouse
Rat
Dog
phosphatase and tensin homolog
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P60484-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (118)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Deubiquitination
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream TCR signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Deubiquitination
Disease
Diseases of signal transduction
Downstream TCR signaling
Gene Ontology Terms (137)
Items per page:
10
1 – 10 of 17
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (883)
1 – 10 of 883
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.997
Data Source: STRINGDB
PIK3CA
Tclin
Family: Kinase
Novelty: 0.00044273
Score: 0.996
Data Source: STRINGDB
PTK2
Tclin
Family: Kinase
Novelty: 0.00066622
Score: 0.993
Data Source: STRINGDB
SLC9A3R1
Tbio
Family: Transporter
Novelty: 0.00357766
Score: 0.991
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.99
Data Source: STRINGDB
PIK3R1
Tchem
Family: Kinase
Novelty: 0.00179772
Score: 0.988
Data Source: STRINGDB
USP7
Tchem
Family: Enzyme
Novelty: 0.00412878
Score: 0.984
Data Source: Reactome,STRINGDB
PDGFRB
Tclin
Family: Kinase
Novelty: 0.00074896
Score: 0.983
Data Source: STRINGDB
PIK3CB
Tchem
Family: Kinase
Novelty: 0.00390277
Score: 0.982
Data Source: STRINGDB
PIK3R2
Tbio
Family: Enzyme
Novelty: 0.00829659
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  7893.93

PubMed score by year
PubTator Score  4795.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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