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Tbio
ADAMTS13
A disintegrin and metalloproteinase with thrombospondin motifs 13

Protein Classes
Protein Summary
Description
Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355699
  • ENSP00000347927
  • ENSG00000160323
  • ENST00000356589
  • ENSP00000348997
  • ENST00000371929
  • ENSP00000360997
  • ENST00000626597
  • ENSP00000486201
  • ENSG00000281244
  • ENST00000626744
  • ENSP00000486734
  • ENST00000630465
  • ENSP00000485989

Symbol
  • C9orf8
  • VWFCP
  • C9orf8
  • vWF-CP
  • ADAM-TS13
  • ADAMTS-13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
molecular function
0.73
protein domain
0.73
tissue sample
0.71
cellular component
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1789.32   (req: < 5)
Gene RIFs: 389   (req: <= 3)
Antibodies: 339   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1789.32   (req: >= 5)
Gene RIFs: 389   (req: > 3)
Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
1
1
97.1
venous thromboembolism
1
1
1
97.1
ADAMTS13 activity measurement
1
2
0
12.3
96.7
ADAMTS13 activity measurement
1
2
0
12.3
96.7
a disintegrin and metalloproteinase with thrombospondin motifs 13
1
1
0
7.1
91.6
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
97.1
venous thromboembolism
1
97.1
ADAMTS13 activity measurement
0
12.3
96.7
ADAMTS13 activity measurement
0
12.3
96.7
a disintegrin and metalloproteinase with thrombospondin motifs 13
0
7.1
91.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 13
VGNC:50888
473153
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 13
722202
Mouse
MGI:2685556
279028
Rat
RGD:1311594
102554393
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 13
VGNC:37592
100630922
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase with thrombospondin type 1 motif 13
Macaque
ADAM metallopeptidase with thrombospondin type 1 motif 13
Mouse
Rat
Dog
ADAM metallopeptidase with thrombospondin type 1 motif 13
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (48)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Protein-Protein Interactions (105)
1 – 10 of 105
VWF
Tbio
Novelty: 0.00009007
Score: 0.973
Data Source: STRINGDB
POFUT2
Tbio
Family: Enzyme
Novelty: 0.06236603
Score: 0.963
Data Source: STRINGDB
B3GLCT
Tbio
Family: Enzyme
Novelty: 0.02398944
Score: 0.945
Data Source: STRINGDB
ADAMTS10
Tbio
Family: Enzyme
Novelty: 0.03532209
Score: 0.928
Data Source: STRINGDB
ADAMTSL2
Tbio
Novelty: 0.05511648
Score: 0.928
Data Source: STRINGDB
THBS1
Tbio
Novelty: 0.00073905
Score: 0.926
Data Source: STRINGDB
SPON1
Tbio
Novelty: 0.01071398
Score: 0.925
Data Source: STRINGDB
ADAMTSL1
Tbio
Novelty: 0.08853044
Score: 0.925
Data Source: STRINGDB
ADAMTS7
Tbio
Family: Enzyme
Novelty: 0.02347655
Score: 0.925
Data Source: STRINGDB
ADAMTS2
Tbio
Family: Enzyme
Novelty: 0.00852208
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  1789.32

PubMed score by year
PubTator Score  1546.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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