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Tchem
AGTR2
Type-2 angiotensin II receptor

Protein Summary
Description
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371906
  • ENSP00000360973
  • ENSG00000180772

Symbol
  • AT2
  • ATGR2
  • MRX88
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.79
gene perturbation
0.76
chemical
0.68
disease
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1468.98   (req: < 5)
Gene RIFs: 143   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1468.98   (req: >= 5)
Gene RIFs: 143   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 248
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lung disease associated with cystic fibrosis
1
2
2
8.4
1
1
0
1.9
5.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lung disease associated with cystic fibrosis
2
8.4
0
1.9
5.4
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (329)
1 – 10 of 329
AGT
Tbio
Novelty: 0.00049613
Score: 0.993
Data Source: Reactome,STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.966
Data Source: STRINGDB
EDN1
Tbio
Novelty: 0.00007453
Score: 0.956
Data Source: STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.947
Data Source: STRINGDB
EDN2
Tbio
Novelty: 0.00203492
Score: 0.945
Data Source: STRINGDB
GNAI3
Tbio
Novelty: 0.03484857
Score: 0.944
Data Source: STRINGDB
GNAI2
Tbio
Novelty: 0.03014729
Score: 0.944
Data Source: STRINGDB
ADRA2C
Tclin
Family: GPCR
Novelty: 0.00661399
Score: 0.942
Data Source: STRINGDB
ADRA2A
Tclin
Family: GPCR
Novelty: 0.00273659
Score: 0.941
Data Source: STRINGDB
ADRA2B
Tclin
Family: GPCR
Novelty: 0.00633206
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  1468.98

PubMed score by year
PubTator Score  667.93

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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