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Tbio
STIL
SCL-interrupting locus protein

Protein Summary
Description
Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphory ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360380
  • ENSP00000353544
  • ENSG00000123473
  • ENST00000371877
  • ENSP00000360944

Symbol
  • SIL
  • SIL
  • MCPH7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
histone modification site profile
0.9
gene perturbation
0.69
transcription factor binding site profile
0.66
cell line
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.34   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.34   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
1
1
1
6.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
1
6.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
STIL, centriolar assembly protein
VGNC:14848
469313
Macaque
STIL, centriolar assembly protein
710099
Mouse
MGI:107477
20460
Rat
RGD:1304972
313506
Dog
STIL, centriolar assembly protein
VGNC:46900
610305
Species
Name
OMA
EggNOG
Inparanoid
Chimp
STIL, centriolar assembly protein
Macaque
STIL, centriolar assembly protein
Mouse
Rat
Dog
STIL, centriolar assembly protein
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15468-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (22)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (164)
1 – 10 of 164
CDC16
Tbio
Novelty: 0.00916715
p_int: 0.999935498
p_ni: 0.000064502
Data Source: BioPlex
DISC1
Tbio
Novelty: 0.00183442
p_int: 0.998644885
p_ni: 0.001355113
p_wrong: 2e-9
Data Source: BioPlex
C6orf141
Tdark
Novelty: 1.46022784
p_int: 0.985729186
p_ni: 0.014270814
Data Source: BioPlex
BBS7
Tbio
Novelty: 0.03611111
p_int: 0.978000511
p_ni: 0.021999484
p_wrong: 4e-9
Data Source: BioPlex
DEF8
Tdark
Novelty: 0.21146806
p_int: 0.974115554
p_ni: 0.025884441
p_wrong: 6e-9
Data Source: BioPlex
CCNJL
Tdark
Novelty: 2.86306774
p_int: 0.972667551
p_ni: 0.027332448
Data Source: BioPlex
LYPD4
Tbio
Novelty: 0.00381728
p_int: 0.937795584
p_ni: 0.062204416
Data Source: BioPlex
IQCF2
Tdark
Novelty: 12.69230769
p_int: 0.932210121
p_ni: 0.06778219
p_wrong: 0.000007689
Data Source: BioPlex
AARSD1
Tdark
Novelty: 0.75372406
p_int: 0.931447704
p_ni: 0.068552296
Data Source: BioPlex
TKT
Tchem
Family: Enzyme
Novelty: 0.00333936
p_int: 0.931126414
p_ni: 0.068873581
p_wrong: 5e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  95.34

PubMed score by year
PubTator Score  599.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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