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Tbio
IFIT1
Interferon-induced protein with tetratricopeptide repeats 1

Protein Summary
Description
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. T ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371804
  • ENSP00000360869
  • ENSG00000185745
  • ENST00000546318
  • ENSP00000441968

Symbol
  • G10P1
  • IFI56
  • IFNAI1
  • ISG56
  • C56
  • P56
  • G10P1
  • IFI56
  • ISG56
  • IFI-56
  • IFIT-1
  • IFNAI1
  • RNM561
  • IFI-56K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.97
small molecule perturbation
0.96
transcription factor perturbation
0.91
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.08   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.08   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
ISG15 antiviral mechanism
Reactome
Immune System
Reactome
Interferon Signaling
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
ISG15 antiviral mechanism
Immune System
Interferon Signaling
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (214)
1 – 10 of 214
IFIT2
Tbio
Novelty: 0.01023074
p_int: 0.999999809
p_ni: 1.91e-7
Score: 0.997
Data Source: BioPlex,STRINGDB
PHACTR4
Tbio
Family: Enzyme
Novelty: 0.11366977
p_int: 0.99999923
p_ni: 4.25e-7
p_wrong: 3.45e-7
Score: 0.691
Data Source: BioPlex,STRINGDB
IFNA7
Tdark
Novelty: 0.14618009
p_int: 0.999961845
p_ni: 0.000025971
p_wrong: 0.000012184
Score: 0.161
Data Source: BioPlex,STRINGDB
IFNA21
Tbio
Novelty: 0.00581034
p_int: 0.999612935
p_ni: 0.000365108
p_wrong: 0.000021957
Score: 0.634
Data Source: BioPlex,STRINGDB
IFNA8
Tbio
Novelty: 0.0310922
p_int: 0.999497627
p_ni: 0.000502371
p_wrong: 3e-9
Score: 0.303
Data Source: BioPlex,STRINGDB
IFNA14
Tbio
Novelty: 0.17853653
p_int: 0.999474975
p_ni: 0.000525024
p_wrong: 1e-9
Score: 0.871
Data Source: BioPlex,STRINGDB
IFNA10
Tbio
Novelty: 0.04848204
p_int: 0.999111822
p_ni: 0.000697794
p_wrong: 0.000190384
Score: 0.354
Data Source: BioPlex,STRINGDB
IFNA5
Tbio
Novelty: 0.02838784
p_int: 0.997622525
p_ni: 0.00232999
p_wrong: 0.000047485
Score: 0.772
Data Source: BioPlex,STRINGDB
IFIT3
Tbio
Novelty: 0.00568113
Score: 0.999
Data Source: STRINGDB
MX1
Tbio
Novelty: 0.00072554
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  161.08

PubMed score by year
PubTator Score  543.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer