You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LCN8
Epididymal-specific lipocalin-8

Protein Summary
Description
May play a role in male fertility. May act as a retinoid carrier protein within the epididymis. Members of the lipocalin family, such as LCN8, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371688
  • ENSP00000360753
  • ENSG00000204001
  • ENST00000612714
  • ENSP00000482512

Symbol
  • LCN5
  • EP17
  • LCN5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
cell type or tissue
0.7
cell line
0.48
tissue
0.45
kinase perturbation
0.42


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.74   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.74   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipocalin 8
VGNC:13910
464872
Macaque
lipocalin 8
709395
Mouse
MGI:2135945
78076
Rat
RGD:1306747
366008
Dog
lipocalin 8
VGNC:42613
607230
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipocalin 8
Macaque
lipocalin 8
Mouse
Rat
Dog
lipocalin 8
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (31)
1 – 10 of 31
NUB1
Tbio
Novelty: 0.00736082
p_int: 0.999995539
p_ni: 0.000004417
p_wrong: 4.4e-8
Data Source: BioPlex
FAHD2A
Tdark
Family: Enzyme
Novelty: 0.68981789
p_int: 0.939326111
p_ni: 0.060250733
p_wrong: 0.000423155
Data Source: BioPlex
LRRC41
Tbio
Novelty: 0.12601472
p_int: 0.919506766
p_ni: 0.080493234
Data Source: BioPlex
MADD
Tbio
Family: Enzyme
Novelty: 0.01590443
p_int: 0.916428041
p_ni: 0.083571959
Data Source: BioPlex
WDR45
Tbio
Novelty: 0.0148072
p_int: 0.90659292
p_ni: 0.087003685
p_wrong: 0.006403395
Data Source: BioPlex
PKN2
Tchem
Family: Kinase
Novelty: 0.0088412
p_int: 0.783956181
p_ni: 0.216043819
Data Source: BioPlex
LCN9
Tdark
Novelty: 0.25490072
Score: 0.797
Data Source: STRINGDB
CST11
Tbio
Novelty: 0.0327324
Score: 0.721
Data Source: STRINGDB
LCN6
Tbio
Novelty: 0.11406686
Score: 0.672
Data Source: STRINGDB
LCN15
Tdark
Novelty: 0.54935158
Score: 0.643
Data Source: STRINGDB
Publication Statistics
PubMed Score  39.74

PubMed score by year
PubTator Score  3.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer