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Tbio
LGI1
Leucine-rich glioma-inactivated protein 1

Protein Summary
Description
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371413
  • ENSP00000360467
  • ENSG00000108231
  • ENST00000371418
  • ENSP00000360472
  • ENST00000630047
  • ENSP00000485917

Symbol
  • EPT
  • EPT
  • ETL1
  • ADLTE
  • ADPAEF
  • ADPEAF
  • IB1099
  • EPITEMPIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
protein domain
0.85
kinase perturbation
0.76
gene perturbation
0.68
biological term
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 544.4   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 544.4   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich glioma inactivated 1
450619
Macaque
leucine rich glioma inactivated 1
700520
Mouse
MGI:1861691
56839
Rat
RGD:628742
252892
Dog
leucine rich glioma inactivated 1
477777
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich glioma inactivated 1
Macaque
leucine rich glioma inactivated 1
Mouse
Rat
Dog
leucine rich glioma inactivated 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95970-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
LGI-ADAM interactions
Name
Explore in Pharos
Explore in Source
Developmental Biology
LGI-ADAM interactions
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
DFLAT
Protein-Protein Interactions (97)
1 – 10 of 97
ADAM22
Tbio
Family: Enzyme
Novelty: 0.01981755
Score: 0.998
Data Source: Reactome,STRINGDB
ADAM23
Tbio
Family: Enzyme
Novelty: 0.02974247
Score: 0.984
Data Source: Reactome,STRINGDB
CACNG2
Tbio
Family: IC
Novelty: 0.00808502
Score: 0.973
Data Source: Reactome,STRINGDB
ADAM11
Tbio
Family: Enzyme
Novelty: 0.122537
Score: 0.96
Data Source: Reactome,STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.957
Data Source: Reactome,STRINGDB
CNTNAP2
Tbio
Novelty: 0.00238905
Score: 0.927
Data Source: STRINGDB
CACNG3
Tbio
Family: IC
Novelty: 0.32654561
Score: 0.918
Data Source: Reactome,STRINGDB
CACNG4
Tbio
Family: IC
Novelty: 0.15976593
Score: 0.914
Data Source: Reactome,STRINGDB
CACNG8
Tdark
Family: IC
Novelty: 0.26770379
Score: 0.911
Data Source: Reactome,STRINGDB
ADAM28
Tbio
Family: Enzyme
Novelty: 0.01239522
Score: 0.817
Data Source: STRINGDB
Publication Statistics
PubMed Score  544.40

PubMed score by year
PubTator Score  307.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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