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Tbio
NKAP
NF-kappa-B-activating protein

Protein Summary
Description
Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371410
  • ENSP00000360464
  • ENSG00000101882
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
drug perturbation
0.71
tissue sample
0.68
histone modification site profile
0.62
ligand (protein) perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.63   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.63   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (87)
1 – 10 of 87
CSNK2A2
Tchem
Family: Kinase
Novelty: 0.00231447
p_int: 0.999999998
p_ni: 2e-9
Score: 0.664
Data Source: BioPlex,STRINGDB
NKAPL
Tbio
Novelty: 0.24172313
p_int: 0.999999979
p_ni: 2e-8
Score: 0.218
Data Source: BioPlex,STRINGDB
NOS1AP
Tbio
Family: Enzyme
Novelty: 0.0076555
p_int: 0.99999136
p_ni: 0.00000864
Score: 0.711
Data Source: BioPlex,STRINGDB
DDX41
Tbio
Family: Enzyme
Novelty: 0.01658581
p_int: 0.99998384
p_ni: 0.00001616
Score: 0.726
Data Source: BioPlex,STRINGDB
C1orf226
Tdark
Novelty: 3.45031712
p_int: 0.999976975
p_ni: 0.00000856
p_wrong: 0.000014465
Score: 0.19
Data Source: BioPlex,STRINGDB
CSNK2A1
Tchem
Family: Kinase
Novelty: 0.00187855
p_int: 0.999970625
p_ni: 0.000029375
Score: 0.444
Data Source: BioPlex,STRINGDB
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.999759283
p_ni: 0.000240717
Data Source: BioPlex
NINL
Tbio
Novelty: 0.00726815
p_int: 0.999694167
p_ni: 0.000295559
p_wrong: 0.000010274
Data Source: BioPlex
PRPF40A
Tbio
Novelty: 0.00898047
p_int: 0.998362015
p_ni: 0.001637985
Score: 0.817
Data Source: BioPlex,STRINGDB
CHCHD4
Tbio
Novelty: 0.01204944
p_int: 0.998360964
p_ni: 0.001639036
Data Source: BioPlex
Publication Statistics
PubMed Score  27.63

PubMed score by year
PubTator Score  4.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer