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Tbio
PKHD1
Fibrocystin

Protein Summary
Description
May be required for correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly. May be a receptor protein that acts in collecting-duct and biliary differentiation. The protein encoded by this gene is predicted to have a single transmembrane (TM)-spanning domain and multiple copies of an immunoglobulin-like plexin-transcription-factor domain. Alternative splicing results in two transcript variants encoding different isoforms. Other alternatively spliced transcripts have been described, but the full length sequences have not been determined. Several of these transcripts are predicted to encode truncated products which lack the TM and may be secreted. Mutations in this gene cause autosomal recessive polycystic kidney disease, also known as polycystic kidney and hepatic disease-1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340994
  • ENSP00000341097
  • ENSG00000170927
  • ENST00000371117
  • ENSP00000360158

Symbol
  • FCYT
  • TIGM1
  • FPC
  • FCYT
  • PKD4
  • ARPKD
  • TIGM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.93
microRNA
0.76
biological process
0.75
disease
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.57   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.57   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (25)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (50)
1 – 10 of 50
PKDREJ
Tdark
Family: IC
Novelty: 0.08488564
Score: 0.839
Data Source: STRINGDB
PKD1
Tbio
Novelty: 0.00227305
Score: 0.799
Data Source: STRINGDB
PKD2
Tchem
Family: IC
Novelty: 0.00208049
Score: 0.798
Data Source: STRINGDB
PLXNC1
Tbio
Novelty: 0.03339966
Score: 0.749
Data Source: STRINGDB
PLXNB2
Tbio
Novelty: 0.03410971
Score: 0.747
Data Source: STRINGDB
PLXND1
Tbio
Novelty: 0.0184122
Score: 0.745
Data Source: STRINGDB
PLXNB3
Tbio
Novelty: 0.05652272
Score: 0.742
Data Source: STRINGDB
CAMLG
Tbio
Novelty: 0.01056088
Score: 0.727
Data Source: STRINGDB
RAB8A
Tbio
Family: Enzyme
Novelty: 0.00226947
Score: 0.694
Data Source: STRINGDB
PLXNA3
Tbio
Novelty: 0.01306168
Score: 0.65
Data Source: STRINGDB
Publication Statistics
PubMed Score  62.57

PubMed score by year
PubTator Score  282.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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