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Tbio
FOXD3
Forkhead box protein D3

Protein Summary
Description
Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371116
  • ENSP00000360157
  • ENSG00000187140

Symbol
  • HFH2
  • AIS1
  • HFH2
  • VAMAS2
  • Genesis
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.76
PubMedID
0.71
molecular function
0.7
transcription factor binding site profile
0.67
gene perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.58   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.58   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Reactome
Transcriptional regulation of pluripotent stem cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Transcriptional regulation of pluripotent stem cells
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (108)
1 – 10 of 108
POU5F1
Tbio
Family: TF
Novelty: 0.00033974
Score: 0.984
Data Source: STRINGDB
NANOG
Tbio
Family: TF
Novelty: 0.00054893
Score: 0.979
Data Source: STRINGDB
SOX2
Tbio
Family: TF
Novelty: 0.00037089
Score: 0.973
Data Source: STRINGDB
SOX10
Tbio
Family: TF
Novelty: 0.00130552
Score: 0.931
Data Source: STRINGDB
TFAP2A
Tbio
Family: TF
Novelty: 0.00235655
Score: 0.871
Data Source: STRINGDB
MSX1
Tbio
Family: TF
Novelty: 0.00176212
Score: 0.859
Data Source: STRINGDB
PAX3
Tbio
Family: TF
Novelty: 0.00140464
Score: 0.835
Data Source: STRINGDB
SNAI2
Tbio
Family: TF
Novelty: 0.00096495
Score: 0.819
Data Source: STRINGDB
MITF
Tbio
Family: TF
Novelty: 0.00094044
Score: 0.785
Data Source: STRINGDB
ZIC1
Tbio
Family: TF
Novelty: 0.00491601
Score: 0.762
Data Source: STRINGDB
Publication Statistics
PubMed Score  185.58

PubMed score by year
PubTator Score  71.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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