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Tbio
GNAS
Protein ALEX

Protein Summary
Description
May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame. This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306120
  • ENSP00000302237
  • ENSG00000087460

Symbol
  • GNAS1
  • AHO
  • GSA
  • GSP
  • POH
  • GPSA
  • NESP
  • SCG6
  • SgVI
  • GNAS1
  • PITA3
  • C20orf45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 923.12   (req: < 5)
Gene RIFs: 333   (req: <= 3)
Antibodies: 695   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 923.12   (req: >= 5)
Gene RIFs: 333   (req: > 3)
Antibodies: 695   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (56)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
3
3
12
76
blood urea nitrogen measurement
3
3
12
76
blood urea nitrogen measurement
3
3
12
76
blood urea nitrogen measurement
3
3
12
76
body height
1
1
4
63.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
12
76
blood urea nitrogen measurement
12
76
blood urea nitrogen measurement
12
76
blood urea nitrogen measurement
12
76
body height
4
63.6
Pathways (86)
Aquaporin-mediated transport (R-HSA-445717)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aquaporin-mediated transport
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (i) signalling events
Reactome
G alpha (s) signalling events
Reactome
G alpha (z) signalling events
Name
Explore in Pharos
Explore in Source
Aquaporin-mediated transport
Class B/2 (Secretin family receptors)
G alpha (i) signalling events
G alpha (s) signalling events
G alpha (z) signalling events
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (381)
1 – 10 of 381
GNGT1
Tbio
Novelty: 0.05291961
p_int: 0.999842896
p_ni: 0.000157104
Score: 0.96
Data Source: BioPlex,STRINGDB
GNG2
Tbio
Novelty: 0.04807242
p_int: 0.999761775
p_ni: 0.000238226
Score: 0.993
Data Source: BioPlex,STRINGDB
OR2T10
Tdark
Family: oGPCR
Novelty: 5.20023909
p_int: 0.75213761
p_ni: 0.24786239
Data Source: BioPlex
GNB1
Tbio
Novelty: 0.02477955
Score: 0.992
Data Source: STRINGDB
GNG4
Tbio
Novelty: 0.14371438
Score: 0.984
Data Source: STRINGDB
PRKAR1A
Tbio
Family: Enzyme
Novelty: 0.00311432
Score: 0.979
Data Source: STRINGDB
ADCY2
Tbio
Family: Enzyme
Novelty: 0.01649836
Score: 0.978
Data Source: STRINGDB
TSHR
Tclin
Family: GPCR
Novelty: 0.00074972
Score: 0.97
Data Source: STRINGDB
ADRB2
Tclin
Family: GPCR
Novelty: 0.00041821
Score: 0.969
Data Source: STRINGDB
GNB3
Tbio
Novelty: 0.0037117
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  923.12

PubMed score by year
PubTator Score  1346.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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