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Tbio
LCOR
Ligand-dependent corepressor

Protein Summary
Description
May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356016
  • ENSP00000348298
  • ENSG00000196233
  • ENST00000371097
  • ENSP00000360138
  • ENST00000371103
  • ENSP00000360144
  • ENST00000421806
  • ENSP00000490116
  • ENST00000540664
  • ENSP00000443431

Symbol
  • C10orf12
  • KIAA1795
  • MLR2
  • MLR2
  • C10orf12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.95
transcription factor binding site profile
0.82
transcription factor
0.79
transcription factor perturbation
0.74
virus perturbation
0.59


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.84   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.84   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ligand dependent nuclear receptor corepressor
450647
Macaque
ligand-dependent corepressor
705646
Mouse
MGI:2443930
212391
Mouse
MGI:2685186
Rat
RGD:1311704
365462
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ligand dependent nuclear receptor corepressor
Macaque
ligand-dependent corepressor
Mouse
Mouse
Rat
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96JN0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (40)
1 – 10 of 40
CTBP1
Tbio
Novelty: 0.00243818
p_int: 0.999999998
p_ni: 2e-9
Score: 0.745
Data Source: BioPlex,STRINGDB
SUZ12
Tbio
Novelty: 0.00402353
p_int: 0.99978487
p_ni: 0.000101756
p_wrong: 0.000113375
Score: 0.298
Data Source: BioPlex,STRINGDB
POGZ
Tbio
Novelty: 0.03603188
p_int: 0.999466602
p_ni: 0.000533341
p_wrong: 5.8e-8
Data Source: BioPlex
ZNF516
Tbio
Family: TF
Novelty: 0.22650006
p_int: 0.999400793
p_ni: 0.000599207
Data Source: BioPlex
ASB3
Tbio
Novelty: 0.15921018
p_int: 0.998516341
p_ni: 0.000400726
p_wrong: 0.001082933
Data Source: BioPlex
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.994220889
p_ni: 0.005779111
Data Source: BioPlex
USP7
Tchem
Family: Enzyme
Novelty: 0.00412878
p_int: 0.98369989
p_ni: 0.01630011
Data Source: BioPlex
CTBP2
Tchem
Novelty: 0.00538964
p_int: 0.964949596
p_ni: 0.035050404
Score: 0.34
Data Source: BioPlex,STRINGDB
ZYG11B
Tbio
Novelty: 0.14657862
p_int: 0.952243781
p_ni: 0.047756219
Data Source: BioPlex
LRP1
Tbio
Novelty: 0.00200788
p_int: 0.938226436
p_ni: 0.061773564
Data Source: BioPlex
Publication Statistics
PubMed Score  36.84

PubMed score by year
PubTator Score  23.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer