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Tbio
ITGB3BP
Centromere protein R

Protein Summary
Description
Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271002
  • ENSP00000271002
  • ENSG00000142856
  • ENST00000371092
  • ENSP00000360133
  • ENST00000489099
  • ENSP00000432904

Symbol
  • CENPR
  • NRIF3
  • CENPR
  • NRIF3
  • TAP20
  • CENP-R
  • HSU37139
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
virus perturbation
0.9
transcription factor binding site profile
0.79
biological process
0.71
gene perturbation
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.71   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.71   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
27
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
27
Pathways (23)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (178)
1 – 10 of 178
CENPP
Tbio
Novelty: 0.29282259
p_int: 1
Score: 0.998
Data Source: BioPlex,STRINGDB
CENPO
Tbio
Novelty: 0.12059767
p_int: 1
Score: 0.998
Data Source: BioPlex,STRINGDB
CENPU
Tbio
Novelty: 0.03681625
p_int: 0.999999999
p_ni: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
CENPQ
Tbio
Novelty: 0.19972678
p_int: 0.999998314
p_ni: 0.000001684
p_wrong: 2e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
DGCR8
Tbio
Novelty: 0.00271221
p_int: 0.998546249
p_ni: 0.000776552
p_wrong: 0.000677199
Score: 0.538
Data Source: BioPlex,STRINGDB
CNBP
Tbio
Novelty: 0.00404247
p_int: 0.994225039
p_ni: 0.004935921
p_wrong: 0.000839041
Data Source: BioPlex
MECP2
Tchem
Family: TF
Novelty: 0.00051767
p_int: 0.970029511
p_ni: 0.028692585
p_wrong: 0.001277904
Data Source: BioPlex
CENPN
Tbio
Novelty: 0.06923443
Score: 0.993
Data Source: STRINGDB
CENPT
Tbio
Novelty: 0.03878936
Score: 0.992
Data Source: STRINGDB
CENPI
Tbio
Novelty: 0.01938121
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.71

PubMed score by year
PubTator Score  14.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer