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Tbio
SRSF11
Serine/arginine-rich splicing factor 11

Protein Summary
Description
May function in pre-mRNA splicing. This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370950
  • ENSP00000359988
  • ENSG00000116754
  • ENST00000370951
  • ENSP00000359989

Symbol
  • SFRS11
  • p54
  • NET2
  • SFRS11
  • dJ677H15.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
drug perturbation
0.96
histone modification site profile
0.86
ligand (protein) perturbation
0.83
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.62   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.62   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (10)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (313)
1 – 10 of 313
PUF60
Tbio
Novelty: 0.0330882
p_int: 0.999998566
p_ni: 0.000001434
p_wrong: 1e-9
Score: 0.987
Data Source: BioPlex,STRINGDB
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00134844
p_int: 0.999893355
p_ni: 0.00010664
p_wrong: 6e-9
Score: 0.357
Data Source: BioPlex,STRINGDB
PRM2
Tbio
Novelty: 0.00641454
p_int: 0.800496013
p_ni: 0.199503983
p_wrong: 4e-9
Data Source: BioPlex
SRSF7
Tbio
Novelty: 0.05536211
Score: 0.993
Data Source: STRINGDB
RNPS1
Tbio
Novelty: 0.03863535
Score: 0.989
Data Source: STRINGDB
PNISR
Tdark
Novelty: 0.06710527
Score: 0.986
Data Source: STRINGDB
SRSF3
Tbio
Novelty: 0.0126411
Score: 0.982
Data Source: STRINGDB
SF3B1
Tbio
Novelty: 0.01930575
Score: 0.98
Data Source: STRINGDB
USP39
Tbio
Novelty: 0.00604609
Score: 0.978
Data Source: STRINGDB
SRSF6
Tbio
Novelty: 0.00525642
Score: 0.976
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.62

PubMed score by year
PubTator Score  5.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer