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Tbio
FUBP1
Far upstream element-binding protein 1

Protein Summary
Description
Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294623
  • ENSP00000294623
  • ENSG00000162613
  • ENST00000370768
  • ENSP00000359804

Symbol
  • FBP
  • FUBP
  • hDH V
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.99
protein complex
0.96
transcription factor perturbation
0.96
transcription factor binding site profile
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.85   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.85   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (161)
1 – 10 of 161
PUF60
Tbio
Novelty: 0.0330882
Score: 0.99
Data Source: STRINGDB
FUBP3
Tbio
Novelty: 0.06160164
Score: 0.896
Data Source: STRINGDB
HNRNPF
Tbio
Novelty: 0.02623395
Score: 0.872
Data Source: STRINGDB
KHSRP
Tbio
Novelty: 0.01068889
Score: 0.867
Data Source: STRINGDB
TIAL1
Tbio
Novelty: 0.01026964
Score: 0.866
Data Source: STRINGDB
PCBP1
Tbio
Novelty: 0.01171416
Score: 0.856
Data Source: STRINGDB
KHDRBS1
Tbio
Novelty: 0.00737623
Score: 0.848
Data Source: STRINGDB
PKM
Tchem
Family: Kinase
Novelty: 0.00066016
Score: 0.806
Data Source: STRINGDB
U2AF2
Tbio
Novelty: 0.00739606
Score: 0.787
Data Source: STRINGDB
AIMP2
Tbio
Family: Enzyme
Novelty: 0.03974199
Score: 0.782
Data Source: STRINGDB
Publication Statistics
PubMed Score  49.85

PubMed score by year
PubTator Score  60.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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