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Tbio
SLC9A6
Sodium/hydrogen exchanger 6

Protein Summary
Description
Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis. This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic cognitive disability, Christianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370695
  • ENSP00000359729
  • ENSG00000198689
  • ENST00000370698
  • ENSP00000359732
  • ENST00000370701
  • ENSP00000359735
  • ENST00000636092
  • ENSP00000490406
  • ENST00000636347
  • ENSP00000490648
  • ENST00000637234
  • ENSP00000490527
  • ENST00000637581
  • ENSP00000490731

Symbol
  • KIAA0267
  • NHE6
  • MRSA
  • NHE6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
cellular component
0.87
transcription factor perturbation
0.84
histone modification site profile
0.82
tissue sample
0.73


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.92   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.92   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 9 member A6
VGNC:7704
473799
Macaque
solute carrier family 9 member A6
710429
Mouse
MGI:2443511
236794
Rat
RGD:1563582
302863
Dog
solute carrier family 9 member A6
VGNC:46488
481060
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 9 member A6
Macaque
solute carrier family 9 member A6
Mouse
Rat
Dog
solute carrier family 9 member A6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q92581-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) (R-HSA-5619092)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
SLC transporter disorders
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH)
Disease
Disorders of transmembrane transporters
SLC transporter disorders
SLC-mediated transmembrane transport
Gene Ontology Terms (24)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (73)
1 – 10 of 73
SLC9A7
Tbio
Family: Transporter
Novelty: 0.03560989
p_int: 0.999999996
p_wrong: 4e-9
Score: 0.357
Data Source: BioPlex,STRINGDB
MBLAC2
Tdark
Family: Enzyme
Novelty: 0.47407992
p_int: 0.999997184
p_ni: 0.000002816
Data Source: BioPlex
FUT8
Tbio
Family: Enzyme
Novelty: 0.00675388
p_int: 0.999966616
p_ni: 0.000033384
Data Source: BioPlex
TBC1D32
Tbio
Novelty: 0.25744084
p_int: 0.999953709
p_ni: 0.000035251
p_wrong: 0.00001104
Score: 0.173
Data Source: BioPlex,STRINGDB
CDK20
Tbio
Family: Kinase
Novelty: 0.01176977
p_int: 0.999891572
p_ni: 0.000076037
p_wrong: 0.000032391
Data Source: BioPlex
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
p_int: 0.999889164
p_ni: 0.000110828
p_wrong: 7e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.999852727
p_ni: 0.000145933
p_wrong: 0.000001341
Score: 0.209
Data Source: BioPlex,STRINGDB
DNAJC30
Tdark
Novelty: 0.57178901
p_int: 0.999839517
p_ni: 0.000159216
p_wrong: 0.000001267
Score: 0.196
Data Source: BioPlex,STRINGDB
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999828624
p_ni: 0.000171375
Data Source: BioPlex
COA1
Tbio
Family: Enzyme
Novelty: 0.49194068
p_int: 0.999148709
p_ni: 0.000851275
p_wrong: 1.6e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  75.92

PubMed score by year
PubTator Score  73.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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