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Tbio
CTBS
Di-N-acetylchitobiase

Protein Summary
Description
Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase. Chitobiase is a lysosomal glycosidase involved in degradation of asparagine-linked oligosaccharides on glycoproteins (Aronson and Kuranda, 1989 [PubMed 2531691]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370630
  • ENSP00000359664
  • ENSG00000117151

Symbol
  • CTB
  • CTB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
protein domain
0.73
microRNA
0.63
histone modification site profile
0.62
cellular component
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.62   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.62   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (35)
1 – 10 of 35
MARVELD2
Tbio
Novelty: 0.01661397
p_int: 0.999997582
p_ni: 0.00000174
p_wrong: 6.79e-7
Score: 0.325
Data Source: BioPlex,STRINGDB
DEFA1
Tbio
Novelty: 0.01616437
p_int: 0.999940077
p_ni: 0.000056363
p_wrong: 0.00000356
Score: 0.2
Data Source: BioPlex,STRINGDB
RELB
Tbio
Family: TF
Novelty: 0.00324831
p_int: 0.999679716
p_ni: 0.000060059
p_wrong: 0.000260225
Score: 0.214
Data Source: BioPlex,STRINGDB
PATE1
Tbio
Novelty: 0.03158921
p_int: 0.98558599
p_ni: 0.013788332
p_wrong: 0.000625678
Data Source: BioPlex
GNG5
Tbio
Novelty: 0.21523747
Score: 0.931
Data Source: STRINGDB
PGF
Tclin
Novelty: 0.00083001
Score: 0.723
Data Source: STRINGDB
KTN1
Tbio
Novelty: 0.011349
Score: 0.656
Data Source: STRINGDB
ENGASE
Tchem
Family: Enzyme
Novelty: 0.01125387
Score: 0.644
Data Source: STRINGDB
KIF21B
Tbio
Novelty: 0.08260848
Score: 0.628
Data Source: STRINGDB
GCM1
Tbio
Family: TF
Novelty: 0.01415215
Score: 0.569
Data Source: STRINGDB
Publication Statistics
PubMed Score  285.62

PubMed score by year
PubTator Score  99.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer