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Tbio
SOX3
Transcription factor SOX-3

Protein Summary
Description
Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked cognitive disability with growth hormone deficiency. [provided by R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370536
  • ENSP00000359567
  • ENSG00000134595

Symbol
  • PHP
  • GHDX
  • MRGH
  • PHPX
  • SOXB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
gene perturbation
0.77
biological process
0.76
PubMedID
0.76
phenotype
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.74   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.74   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SRY-box 3
696412
Mouse
MGI:98365
20675
Dog
SRY-box 3
VGNC:46679
492178
Pig
SRY-box 3
100623770
Xenopus
SRY-box 3
XB-GENE-484815
493228
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SRY-box 3
Mouse
Dog
SRY-box 3
Pig
SRY-box 3
Xenopus
SRY-box 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P41225-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Deactivation of the beta-catenin transactivating complex
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Gene Ontology Terms (16)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (144)
1 – 10 of 144
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.929
Data Source: STRINGDB
PAX6
Tbio
Family: TF
Novelty: 0.00064695
Score: 0.904
Data Source: STRINGDB
POU5F1
Tbio
Family: TF
Novelty: 0.00033974
Score: 0.781
Data Source: STRINGDB
DMRT1
Tbio
Family: TF
Novelty: 0.00403133
Score: 0.767
Data Source: STRINGDB
ARSE
Tbio
Family: Enzyme
Novelty: 0.00151862
Score: 0.757
Data Source: STRINGDB
OTX2
Tbio
Family: TF
Novelty: 0.0024536
Score: 0.756
Data Source: STRINGDB
ATXN1
Tbio
Novelty: 0.00419081
Score: 0.75
Data Source: STRINGDB
NES
Tbio
Novelty: 0.00035379
Score: 0.739
Data Source: STRINGDB
NANOG
Tbio
Family: TF
Novelty: 0.00054893
Score: 0.721
Data Source: STRINGDB
HESX1
Tbio
Family: TF
Novelty: 0.00806405
Score: 0.719
Data Source: STRINGDB
Publication Statistics
PubMed Score  372.74

PubMed score by year
PubTator Score  130.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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