You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PAX2
Paired box protein Pax-2

Protein Summary
Description
Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS. PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355243
  • ENSP00000347385
  • ENSG00000075891
  • ENST00000370296
  • ENSP00000359319
  • ENST00000428433
  • ENSP00000396259

Symbol
  • FSGS7
  • PAPRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.91
biological term
0.83
phenotype
0.77
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 637.36   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 424   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 637.36   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 424   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 71
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to recovery post exercise
5
2
5
82.4
heart rate response to exercise
2
3
3
78.9
body mass index
2
1
2
31.9
alcohol consumption measurement
3
1
3
10.6
refractive error measurement
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to recovery post exercise
5
82.4
heart rate response to exercise
3
78.9
body mass index
2
31.9
alcohol consumption measurement
3
10.6
refractive error measurement
1
5.8
Gene Ontology Terms (79)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (213)
1 – 10 of 213
WT1
Tbio
Family: TF
Novelty: 0.00034353
Score: 0.966
Data Source: STRINGDB
PAXIP1
Tbio
Novelty: 0.01728724
Score: 0.891
Data Source: STRINGDB
LHX1
Tbio
Family: TF
Novelty: 0.01291002
Score: 0.87
Data Source: STRINGDB
EYA1
Tbio
Novelty: 0.00585286
Score: 0.869
Data Source: STRINGDB
SHH
Tchem
Novelty: 0.00028347
Score: 0.853
Data Source: STRINGDB
WNT4
Tbio
Novelty: 0.00276803
Score: 0.841
Data Source: STRINGDB
ETS1
Tbio
Family: TF
Novelty: 0.00105233
Score: 0.837
Data Source: STRINGDB
LMX1B
Tbio
Family: TF
Novelty: 0.00405645
Score: 0.835
Data Source: STRINGDB
SOX2
Tbio
Family: TF
Novelty: 0.00037089
Score: 0.833
Data Source: STRINGDB
GBX2
Tbio
Family: TF
Novelty: 0.01248026
Score: 0.826
Data Source: STRINGDB
Publication Statistics
PubMed Score  637.36

PubMed score by year
PubTator Score  352.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: