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Tbio
GCLM
Glutamate--cysteine ligase regulatory subunit

Protein Classes
Protein Summary
Description
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370238
  • ENSP00000359258
  • ENSG00000023909
  • ENST00000615724
  • ENSP00000484507

Symbol
  • GLCLR
  • GLCLR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
transcription factor binding site profile
0.93
chemical
0.89
disease
0.82
PubMedID
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.63   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 394   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.63   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (28)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Reactome
Disease
Reactome
Diseases of metabolism
Reactome
Glutathione conjugation
Name
Explore in Pharos
Explore in Source
Biological oxidations
Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Disease
Diseases of metabolism
Glutathione conjugation
Gene Ontology Terms (29)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (104)
1 – 10 of 104
GCLC
Tchem
Family: Enzyme
Novelty: 0.00217206
p_int: 0.999999891
p_ni: 1.09e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PRKCA
Tchem
Family: Kinase
Novelty: 0.00057611
p_int: 0.99969649
p_ni: 0.000303016
p_wrong: 4.94e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
PARP12
Tbio
Family: Enzyme
Novelty: 0.08076657
p_int: 0.998023847
p_ni: 0.001963499
p_wrong: 0.000012654
Score: 0.197
Data Source: BioPlex,STRINGDB
UROS
Tbio
Family: Enzyme
Novelty: 0.00938683
p_int: 0.975193122
p_ni: 0.001605464
p_wrong: 0.023201414
Score: 0.34
Data Source: BioPlex,STRINGDB
RNF7
Tbio
Novelty: 0.02532658
p_int: 0.973144143
p_ni: 0.026853231
p_wrong: 0.000002626
Data Source: BioPlex
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
p_int: 0.97175221
p_ni: 0.002999543
p_wrong: 0.025248247
Data Source: BioPlex
TRPV5
Tchem
Family: IC
Novelty: 0.0055156
p_int: 0.965431228
p_ni: 0.001727511
p_wrong: 0.032841261
Score: 0.207
Data Source: BioPlex,STRINGDB
SEMA4C
Tbio
Novelty: 0.01237067
p_int: 0.95791765
p_ni: 0.041379401
p_wrong: 0.000702949
Data Source: BioPlex
DNA2
Tbio
Family: Enzyme
Novelty: 0.00195682
p_int: 0.929316648
p_ni: 0.009643911
p_wrong: 0.061039441
Score: 0.184
Data Source: BioPlex,STRINGDB
IFT20
Tbio
Novelty: 0.03005088
p_int: 0.814669048
p_ni: 0.185325729
p_wrong: 0.000005223
Data Source: BioPlex
Publication Statistics
PubMed Score  251.63

PubMed score by year
PubTator Score  83.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer