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Tbio
FBXW4
F-box/WD repeat-containing protein 4

Protein Summary
Description
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling. This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331272
  • ENSP00000359149
  • ENSG00000107829

Symbol
  • FBW4
  • SHFM3
  • DAC
  • FBW4
  • FBWD4
  • SHFM3
  • SHSF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
histone modification site profile
0.81
transcription factor binding site profile
0.66
protein domain
0.58
transcription factor
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.75   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.75   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
23.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
23.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1354698
30838
Rat
RGD:1306518
309444
Dog
F-box and WD repeat domain containing 4
VGNC:40795
486852
Horse
F-box and WD repeat domain containing 4
VGNC:17966
100070086
Cow
F-box and WD repeat domain containing 4
VGNC:28924
513977
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
F-box and WD repeat domain containing 4
Horse
F-box and WD repeat domain containing 4
Cow
F-box and WD repeat domain containing 4
Pathways (10)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (361)
1 – 10 of 361
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.998839879
p_ni: 3.26e-7
p_wrong: 0.001159794
Score: 0.957
Data Source: BioPlex,STRINGDB
CCT3
Tbio
Novelty: 0.01642521
p_int: 0.998707234
p_ni: 0.001292766
Score: 0.96
Data Source: BioPlex,STRINGDB
CCT4
Tbio
Novelty: 0.01176123
p_int: 0.996740908
p_ni: 0.003259092
Score: 0.95
Data Source: BioPlex,STRINGDB
CCT2
Tbio
Novelty: 0.01967139
p_int: 0.991577852
p_ni: 0.008422148
Score: 0.919
Data Source: BioPlex,STRINGDB
CCT6A
Tbio
Novelty: 0.02368046
p_int: 0.978041231
p_ni: 0.021958769
Score: 0.923
Data Source: BioPlex,STRINGDB
CCT7
Tbio
Novelty: 0.02247038
p_int: 0.963200969
p_ni: 0.036799031
Score: 0.961
Data Source: BioPlex,STRINGDB
TCP1
Tbio
Novelty: 0.00395241
p_int: 0.947056998
p_ni: 0.052943002
Score: 0.949
Data Source: BioPlex,STRINGDB
PDCL3
Tbio
Novelty: 0.05786581
p_int: 0.940398224
p_ni: 0.059601776
Score: 0.808
Data Source: BioPlex,STRINGDB
CCT6B
Tdark
Novelty: 0.28933315
p_int: 0.911066466
p_ni: 0.088933534
Score: 0.908
Data Source: BioPlex,STRINGDB
ANKRD39
Tdark
Novelty: 8.68843298
p_int: 0.900519659
p_ni: 5.4e-8
p_wrong: 0.099480287
Data Source: BioPlex
Publication Statistics
PubMed Score  17.75

PubMed score by year
PubTator Score  23.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer