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Tbio
TNFRSF6B
Tumor necrosis factor receptor superfamily member 6B

Protein Summary
Description
Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369996
  • ENSP00000359013
  • ENSG00000243509

Symbol
  • DCR3
  • TR6
  • M68
  • TR6
  • DCR3
  • M68E
  • DJ583P15.1.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.82
disease
0.79
phenotype
0.7
tissue sample
0.58
tissue
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 327.85   (req: < 5)
Gene RIFs: 116   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 327.85   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.3
81.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
81.4
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
TNF receptor superfamily member 6b
VGNC:47666
102152544
Cow
TNF receptor superfamily member 6b
VGNC:36169
789154
Chicken
TNF receptor superfamily member 6b
CGNC:49168
395096
Anole lizard
TNF receptor superfamily member 6b [Source:HGNC Symbol;Acc:HGNC:11921]
Species
Name
OMA
EggNOG
Inparanoid
Dog
TNF receptor superfamily member 6b
Cow
TNF receptor superfamily member 6b
Chicken
TNF receptor superfamily member 6b
Anole lizard
TNF receptor superfamily member 6b [Source:HGNC Symbol;Acc:HGNC:11921]
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95407-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (94)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (32)
1 – 10 of 32
TNFSF15
Tbio
Novelty: 0.00225303
Score: 0.976
Data Source: Reactome,STRINGDB
FASLG
Tbio
Novelty: 0.0003303
Score: 0.97
Data Source: STRINGDB
TNFSF14
Tbio
Novelty: 0.01370893
Score: 0.965
Data Source: Reactome,STRINGDB
RTEL1
Tbio
Family: Enzyme
Novelty: 0.00761538
Score: 0.814
Data Source: STRINGDB
TNF
Tclin
Novelty: 0.00001457
Score: 0.691
Data Source: STRINGDB
NR2C2
Tchem
Family: NR
Novelty: 0.00392355
Score: 0.67
Data Source: STRINGDB
TNFRSF25
Tbio
Novelty: 0.0005039
Score: 0.63
Data Source: STRINGDB
STMN1
Tbio
Novelty: 0.00117369
Score: 0.626
Data Source: STRINGDB
NAA10
Tbio
Family: Enzyme
Novelty: 0.00086809
Score: 0.585
Data Source: STRINGDB
TNFRSF1A
Tchem
Novelty: 0.00037847
Score: 0.543
Data Source: STRINGDB
Publication Statistics
PubMed Score  327.85

PubMed score by year
PubTator Score  178.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer