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Tbio
CNNM2
Metal transporter CNNM2

Protein Summary
Description
Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369875
  • ENSP00000358891
  • ENSG00000148842
  • ENST00000369878
  • ENSP00000358894
  • ENST00000433628
  • ENSP00000392875

Symbol
  • ACDP2
  • ACDP2
  • HOMG6
  • HOMGSMR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
disease perturbation
0.9
trait
0.75
histone modification site profile
0.74
tissue sample
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.25   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.25   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
0
1.1
98.7
worry measurement
2
4
2
7.3
92.8
2
2
2
78.6
2
2
1
1.1
76.8
diastolic blood pressure
2
2
2
75.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
98.7
worry measurement
2
7.3
92.8
2
78.6
1
1.1
76.8
diastolic blood pressure
2
75.2
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (76)
1 – 10 of 76
PTP4A1
Tchem
Family: Enzyme
Novelty: 0.02863007
p_int: 0.999495999
p_ni: 0.000504001
Score: 0.982
Data Source: BioPlex,STRINGDB
ARL15
Tbio
Family: Enzyme
Novelty: 0.09327102
p_int: 0.987953544
p_ni: 0.012046456
Score: 0.335
Data Source: BioPlex,STRINGDB
PTP4A2
Tchem
Family: Enzyme
Novelty: 0.0083639
p_int: 0.98390447
p_ni: 0.01609553
Score: 0.839
Data Source: BioPlex,STRINGDB
MIA3
Tbio
Novelty: 0.02784348
Score: 0.779
Data Source: STRINGDB
NT5C2
Tbio
Family: Enzyme
Novelty: 0.00758288
Score: 0.747
Data Source: STRINGDB
PTP4A3
Tchem
Family: Enzyme
Novelty: 0.01185448
Score: 0.742
Data Source: STRINGDB
PLPP3
Tbio
Family: Enzyme
Novelty: 0.01655047
Score: 0.73
Data Source: STRINGDB
HPSE2
Tbio
Family: Enzyme
Novelty: 0.00583615
Score: 0.712
Data Source: STRINGDB
SLC41A1
Tbio
Family: Transporter
Novelty: 0.01442757
Score: 0.708
Data Source: STRINGDB
TRPM6
Tchem
Family: Kinase
Novelty: 0.00594821
Score: 0.697
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.25

PubMed score by year
PubTator Score  18.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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