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Tbio
ATP5PB
ATP synthase F(0) complex subunit B1, mitochondrial

Protein Summary
Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphoryla ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369722
  • ENSP00000358737
  • ENSG00000116459

Symbol
  • ATP5F1
  • PIG47
  • ATP5F1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.27   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.27   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (15)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Formation of ATP by chemiosmotic coupling
Reactome
Metabolism
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cristae formation
Formation of ATP by chemiosmotic coupling
Metabolism
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Protein-Protein Interactions (248)
1 – 10 of 248
DNAJC28
Tbio
Novelty: 0.07210816
p_int: 0.999998153
p_ni: 1.29e-7
p_wrong: 0.000001718
Score: 0.795
Data Source: BioPlex,STRINGDB
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.02087315
p_int: 0.999993774
p_ni: 0.000006226
Score: 0.999
Data Source: BioPlex,STRINGDB
ZFYVE27
Tbio
Novelty: 0.0897072
p_int: 0.998331679
p_ni: 0.001668321
Score: 0.552
Data Source: BioPlex,STRINGDB
ATP5F1D
Tbio
Family: Enzyme
Novelty: 0.10560736
p_int: 0.992176821
p_ni: 0.007823179
Score: 0.999
Data Source: BioPlex,STRINGDB
SLC19A2
Tbio
Family: Transporter
Novelty: 0.01022325
p_int: 0.991495442
p_ni: 0.008504558
Score: 0.638
Data Source: BioPlex,STRINGDB
ATP5F1A
Tbio
Family: Enzyme
Novelty: 0.00712157
p_int: 0.990239151
p_ni: 0.009760849
Score: 0.999
Data Source: BioPlex,STRINGDB
DKK3
Tbio
Novelty: 0.00427648
p_int: 0.989417392
p_ni: 0.010582608
Data Source: BioPlex
MT-ATP8
Tbio
Family: Enzyme
Novelty: 0.00394859
p_int: 0.985388179
p_ni: 0.014603111
p_wrong: 0.00000871
Score: 0.987
Data Source: BioPlex,STRINGDB
GPR21
Tdark
Family: GPCR
Novelty: 1
p_int: 0.956450585
p_ni: 0.043549415
Data Source: BioPlex
ATP5F1C
Tbio
Family: Enzyme
Novelty: 0.22004373
p_int: 0.954173426
p_ni: 0.045826574
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.27

PubMed score by year
PubTator Score  2.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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