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Tchem
RAP1A
Ras-related protein Rap-1A

Protein Summary
Description
Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation statu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356415
  • ENSP00000348786
  • ENSG00000116473
  • ENST00000369709
  • ENSP00000358723

Symbol
  • KREV1
  • RAP1
  • C21KG
  • G-22K
  • KREV1
  • KREV-1
  • SMGP21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
molecular function
0.99
biological process
0.98
interacting protein
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 294.53   (req: < 5)
Gene RIFs: 125   (req: <= 3)
Antibodies: 435   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 294.53   (req: >= 5)
Gene RIFs: 125   (req: > 3)
Antibodies: 435   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
86.5
mathematical ability
2
2
2
82.4
intelligence
1
1
1
15.8
1
1
1
15.8
monocyte count
1
1
1
14.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
86.5
mathematical ability
2
82.4
intelligence
1
15.8
1
15.8
monocyte count
1
14.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAP1A, member of RAS oncogene family
VGNC:11815
469408
Macaque
RAP1A, member of RAS oncogene family
704404
Mouse
MGI:97852
109905
Rat
RGD:1359694
295347
Cow
RAP1A, member of RAS oncogene family
VGNC:33715
282031
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAP1A, member of RAS oncogene family
Macaque
RAP1A, member of RAS oncogene family
Mouse
Rat
Cow
RAP1A, member of RAS oncogene family
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P62834-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (102)
ARMS-mediated activation (R-HSA-170984)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 43
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ARMS-mediated activation
Reactome
Adaptive Immune System
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
ARMS-mediated activation
Adaptive Immune System
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Gene Ontology Terms (43)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (352)
1 – 10 of 352
RAP1GDS1
Tbio
Family: Enzyme
Novelty: 0.06140479
p_int: 0.999999609
p_ni: 3.2e-7
p_wrong: 7e-8
Score: 0.596
Data Source: BioPlex,STRINGDB
RGL1
Tbio
Novelty: 0.0095933
p_int: 0.999998931
p_ni: 0.000001069
Score: 0.448
Data Source: BioPlex,STRINGDB
KIFAP3
Tbio
Novelty: 0.01902437
p_int: 0.999969567
p_ni: 0.000030417
p_wrong: 1.7e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
TMEM31
Tdark
Novelty: 0.65381391
p_int: 0.999934622
p_ni: 0.000044795
p_wrong: 0.000020583
Data Source: BioPlex
POLE3
Tbio
Family: Enzyme
Novelty: 0.09657513
p_int: 0.999871412
p_ni: 0.000128429
p_wrong: 1.59e-7
Score: 0.156
Data Source: BioPlex,STRINGDB
MRPL34
Tdark
Novelty: 1.17388411
p_int: 0.99986958
p_ni: 0.000099985
p_wrong: 0.000030435
Data Source: BioPlex
EXOC6
Tbio
Novelty: 0.01886811
p_int: 0.999717595
p_ni: 0.000277223
p_wrong: 0.000005182
Score: 0.5
Data Source: BioPlex,STRINGDB
CPLX2
Tbio
Novelty: 0.01821493
p_int: 0.999694768
p_ni: 0.000029472
p_wrong: 0.00027576
Score: 0.228
Data Source: BioPlex,STRINGDB
RABIF
Tbio
Novelty: 0.22512579
p_int: 0.999677725
p_ni: 0.00020413
p_wrong: 0.000118145
Score: 0.151
Data Source: BioPlex,STRINGDB
TACR3
Tchem
Family: GPCR
Novelty: 0.00351352
p_int: 0.999643537
p_ni: 0.000336441
p_wrong: 0.000020022
Data Source: BioPlex
Publication Statistics
PubMed Score  294.53

PubMed score by year
PubTator Score  539.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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