Tbio WNT2B Protein Wnt-2b

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein Wnt-2b

Protein Summary

Description

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development. This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• Q93097
• O14903
• Q5TEH9
• Q5TEI2
• Q9HDC1
• Q9HDC2

Gene Name

• WNT2B

Ensembl ID

• ENST00000369684
• ENSP00000358698
• ENSG00000134245
• ENST00000369686
• ENSP00000358700

Symbol

• WNT13
• WNT13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.83
transcription factor	0.76
biological process	0.68
pathway	0.68
PubMedID	0.66

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.56   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 226   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.56   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (58)

Reactome (6)

KEGG (13)

PathwayCommons (29)

WikiPathways (10)

Class B/2 (Secretin family receptors) (R-HSA-373080)

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Items per page:

5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by GPCR	1212 targets	R-HSA-372790
Reactome	Signaling by WNT	299 targets	R-HSA-195721

Name	Explore in Pharos	Explore in Source
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
GPCR ligand binding	460 targets	R-HSA-500792
Signal Transduction	2704 targets	R-HSA-162582
Signaling by GPCR	1212 targets	R-HSA-372790
Signaling by WNT	299 targets	R-HSA-195721

Gene Ontology Terms (19)

Functions (1)

Components (3)

Processes (15)

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
frizzled binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (136)

Explore Interacting Targets

1 – 10 of 136

• See Interactions on String-DB

FZD1

Tbio

Family: GPCR

Novelty: 0.00772255

Score: 0.979

Data Source: STRINGDB

FZD4

Tchem

Family: GPCR

Novelty: 0.00765487

Score: 0.977

Data Source: STRINGDB

FZD2

Tbio

Family: GPCR

Novelty: 0.01294873

Score: 0.977

Data Source: STRINGDB

FZD8

Tbio

Family: GPCR

Novelty: 0.02080497

Score: 0.974

Data Source: STRINGDB

FZD7

Tbio

Family: GPCR

Novelty: 0.01307342

Score: 0.973

Data Source: STRINGDB

FZD6

Tbio

Family: GPCR

Novelty: 0.02056934

Score: 0.972

Data Source: STRINGDB

FZD9

Tbio

Family: GPCR

Novelty: 0.01543758

Score: 0.972

Data Source: STRINGDB

FZD5

Tbio

Family: GPCR

Novelty: 0.02565022

Score: 0.971

Data Source: STRINGDB

FZD10

Tbio

Family: GPCR

Novelty: 0.03473251

Score: 0.967

Data Source: STRINGDB

WLS

Tbio

Novelty: 0.0028553

Score: 0.966

Data Source: STRINGDB

Publication Statistics

PubMed Score  83.56

PubMed score by year

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PubTator Score  47.17

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MLRPGGAEEAAQLPLRRASAPVPVPSPAAPDGSRASARLGLACLLLLLLLTLPARVDTSWWYIGALGARV

1-70

ICDNIPGLVSRQRQLCQRYPDIMRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRVMLRSSREAA

70-140

FVYAISSAGVVHAITRACSQGELSVCSCDPYTRGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRL

140-210

KDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFRRTGDYLRRRYDGAVQVMATQD

210-280

GANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGTDGCEIMCCGRGYDTTRVT

280-350

RVTQCECKFHWCCAVRCKECRNTVDVHTCKAPKKAEWLDQT

350-391

MLRPGGAEEAAQLPLRRASAPVPVPSPAAPDGSRASARLGLACLLLLLLLTLPARVDTSWWYIGALGARVICDNIPGLVSRQRQLCQRYPDIMRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYTRGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCKAPKKAEWLDQT

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Uniprot Keyword

Alternative splicing
Complete proteome
Developmental protein
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Reference proteome
Secreted
Signal