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Tbio
TBX18
T-box transcription factor TBX18

Protein Summary
Description
Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area. This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369663
  • ENSP00000358677
  • ENSG00000112837

Symbol
  • CAKUT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
molecular function
0.86
gene perturbation
0.83
transcription factor binding site profile
0.7
tissue
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.04   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.04   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (8)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (53)
1 – 10 of 53
TBX20
Tbio
Family: TF
Novelty: 0.01591161
p_int: 0.999264334
p_ni: 9.34e-7
p_wrong: 0.000734732
Data Source: BioPlex
PAPSS2
Tbio
Family: Enzyme
Novelty: 0.02465931
p_int: 0.974389559
p_ni: 0.025531269
p_wrong: 0.000079172
Data Source: BioPlex
TCF21
Tbio
Family: TF
Novelty: 0.00104257
Score: 0.874
Data Source: STRINGDB
WT1
Tbio
Family: TF
Novelty: 0.00042049
Score: 0.832
Data Source: STRINGDB
NKX2-5
Tbio
Family: TF
Novelty: 0.00147966
Score: 0.818
Data Source: STRINGDB
SHOX2
Tbio
Family: TF
Novelty: 0.01210282
Score: 0.796
Data Source: STRINGDB
GATA4
Tbio
Family: TF
Novelty: 0.00115226
Score: 0.774
Data Source: STRINGDB
ALDH1A2
Tbio
Family: Enzyme
Novelty: 0.00544461
Score: 0.772
Data Source: STRINGDB
IRX4
Tbio
Family: TF
Novelty: 0.05633392
Score: 0.766
Data Source: STRINGDB
HCN4
Tclin
Family: IC
Novelty: 0.00301943
Score: 0.736
Data Source: STRINGDB
Publication Statistics
PubMed Score  66.04

PubMed score by year
PubTator Score  24.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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