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Tdark
FAM19A3
Protein FAM19A3

Protein Summary
Description
Plays a role in the regulation of microglia polarization. This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361886
  • ENSP00000355042
  • ENSG00000184599
  • ENST00000369630
  • ENSP00000358644

Symbol
  • TAFA3
  • TAFA-3
  • FAM19A3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
gene perturbation
0.56
tissue
0.51
transcription factor binding site profile
0.48
cell line
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.2   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.2   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (93)
1 – 10 of 93
FLAD1
Tbio
Family: Enzyme
Novelty: 0.0248227
p_int: 0.999997957
p_ni: 0.000002043
Data Source: BioPlex
DHPS
Tbio
Family: Enzyme
Novelty: 0.01069486
p_int: 0.999986834
p_ni: 0.000013166
Data Source: BioPlex
FUOM
Tbio
Family: Enzyme
Novelty: 0.1
p_int: 0.999959307
p_wrong: 0.000040693
Data Source: BioPlex
MAPK9
Tchem
Family: Kinase
Novelty: 0.00197999
p_int: 0.999951786
p_ni: 0.000048214
Data Source: BioPlex
PPP2R2D
Tbio
Family: Enzyme
Novelty: 0.10054323
p_int: 0.999903579
p_ni: 0.000096421
Data Source: BioPlex
THNSL1
Tdark
Family: Enzyme
p_int: 0.999865866
p_ni: 0.000134133
Data Source: BioPlex
JMJD4
Tbio
Novelty: 0.13265189
p_int: 0.999664555
p_ni: 0.000335433
p_wrong: 1.2e-8
Data Source: BioPlex
PRMT7
Tchem
Family: Epigenetic
Novelty: 0.03626431
p_int: 0.99962315
p_ni: 0.000101859
p_wrong: 0.000274991
Data Source: BioPlex
FAAP100
Tdark
Novelty: 0.7968976
p_int: 0.999473096
p_ni: 0.000526904
Data Source: BioPlex
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00655436
p_int: 0.999426743
p_ni: 0.000573257
Data Source: BioPlex
Publication Statistics
PubMed Score  2.20

PubMed score by year
PubTator Score  0.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer