Protein Classes
Protein Summary
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
- ENST00000345633
- ENSP00000298701
- ENSG00000165806
- ENST00000369315
- ENSP00000358321
- ENST00000369318
- ENSP00000358324
- ENST00000369331
- ENSP00000358337
- ENST00000452490
- ENSP00000398107
- ENST00000614447
- ENSP00000478285
- ENST00000621345
- ENSP00000480584
- ENST00000621607
- ENSP00000478999
- MCH3
- MCH3
- CMH-1
- LICE2
- CASP-7
- ICE-LAP3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
chemical | 1 | ||
virus perturbation | 1 | ||
hub protein | 0.88 | ||
protein domain | 0.85 | ||
gene perturbation | 0.83 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 464.87 (req: < 5)
Gene RIFs: 83 (req: <= 3)
Antibodies: 991 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 464.87 (req: >= 5)
Gene RIFs: 83 (req: > 3)
Antibodies: 991 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 327
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (327)
1 – 10 of 327
Protein Data Bank (41)
1 – 5 of 41
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (108)
Reactome (12)
KEGG (8)
PathwayCommons (10)
WikiPathways (78)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 12
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of caspases through apoptosome-mediated cleavage | ||||
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Apoptotic factor-mediated response | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of caspases through apoptosome-mediated cleavage | ||||
Apoptosis | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Apoptotic factor-mediated response | ||||
Gene Ontology Terms (13)
Functions (5)
Components (4)
Processes (4)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (201)
1 – 10 of 201
CASP8
Family: Enzyme
Novelty: 0.00026844
Score: 0.999
Data Source: STRINGDB
XIAP
Family: Enzyme
Novelty: 0.00068225
Score: 0.996
Data Source: Reactome,STRINGDB
APAF1
Family: Enzyme
Novelty: 0.00164778
Score: 0.993
Data Source: STRINGDB
BIRC2
Novelty: 0.00265344
Score: 0.99
Data Source: STRINGDB
CASP10
Family: Enzyme
Novelty: 0.01037136
Score: 0.988
Data Source: STRINGDB
CYCS
Novelty: 0.00018258
Score: 0.981
Data Source: STRINGDB
BIRC3
Novelty: 0.00226316
Score: 0.981
Data Source: STRINGDB
PARP1
Family: Enzyme
Novelty: 0.00042675
Score: 0.981
Data Source: STRINGDB
CASP2
Family: Enzyme
Novelty: 0.00224248
Score: 0.966
Data Source: STRINGDB
GZMB
Family: Enzyme
Novelty: 0.00040843
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score 464.87
PubMed score by year
PubTator Score 905.88
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKC
1-70
IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACI
70-140
LLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPR
140-210
YKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDP
210-280
HFHEKKQIPCVVSMLTKELYFSQ
280-303
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ
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