You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HIST2H2AA3
Histone H2A type 2-A

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369159
  • ENSP00000358155
  • ENSG00000203812
  • ENST00000607355
  • ENSP00000475814
  • ENSG00000272196

Symbol
  • H2AFO
  • HIST2H2AA
  • H2A/R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
cellular component
0.91
tissue sample
0.66
small molecule perturbation
0.62
disease
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1353.12   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1353.12   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (83)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 80
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (284)
1 – 10 of 284
HIST2H2BE
Tbio
Novelty: 0.00024381
Score: 0.996
Data Source: STRINGDB
HIST1H2BO
Tdark
Novelty: 0.3427419
Score: 0.996
Data Source: STRINGDB
HIST2H2BF
Tdark
Novelty: 1.40321359
Score: 0.995
Data Source: STRINGDB
HIST1H2BK
Tbio
Novelty: 0.12867647
Score: 0.986
Data Source: STRINGDB
HIST2H2AB
Tbio
Novelty: 0.06772132
Score: 0.985
Data Source: STRINGDB
HIST1H2BD
Tbio
Novelty: 0.05094332
Score: 0.972
Data Source: STRINGDB
HIST1H2BN
Tbio
Novelty: 0.02592521
Score: 0.972
Data Source: STRINGDB
HIST1H2AC
Tdark
Novelty: 0.4785744
Score: 0.971
Data Source: STRINGDB
HIST1H2BJ
Tbio
Novelty: 0.14308844
Score: 0.965
Data Source: STRINGDB
HIST2H2AC
Tbio
Novelty: 0.00065524
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  1353.12

PubMed score by year
PubTator Score  13.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer