You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
SV2A
Synaptic vesicle glycoprotein 2A

Protein Summary
Description
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1. The protein encoded by this gene is one of three related synaptic vesicle proteins. The encoded protein may interact with synaptotagmin to enhance low frequency neurotransmission in quiescent neurons. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369145
  • ENSP00000358141
  • ENSG00000159164
  • ENST00000369146
  • ENSP00000358142

Symbol
  • KIAA0736
  • SV2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.71
tissue
0.63
tissue sample
0.6
cellular component
0.57


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 789.7   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 789.7   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
3
5
97.6
2
2
2
68
testosterone measurement
1
1
1
50.4
body height
4
1
3
5.1
38.1
forced expiratory volume
1
1
1
29.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
97.6
2
68
testosterone measurement
1
50.4
body height
3
5.1
38.1
forced expiratory volume
1
29.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptic vesicle glycoprotein 2A
VGNC:1655
457264
Mouse
MGI:1927139
64051
Rat
RGD:619715
117559
Dog
synaptic vesicle glycoprotein 2A
VGNC:47003
100855661
Horse
synaptic vesicle glycoprotein 2A
VGNC:23778
100054302
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptic vesicle glycoprotein 2A
Mouse
Rat
Dog
synaptic vesicle glycoprotein 2A
Horse
synaptic vesicle glycoprotein 2A
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q7L0J3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Infectious disease
Reactome
Neurotoxicity of clostridium toxins
Reactome
Toxicity of botulinum toxin type A (BoNT/A)
Reactome
Toxicity of botulinum toxin type D (BoNT/D)
Name
Explore in Pharos
Explore in Source
Disease
Infectious disease
Neurotoxicity of clostridium toxins
Toxicity of botulinum toxin type A (BoNT/A)
Toxicity of botulinum toxin type D (BoNT/D)
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (129)
1 – 10 of 129
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.997542199
p_ni: 0.002457801
Score: 0.157
Data Source: BioPlex,STRINGDB
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.978789874
p_ni: 0.021210126
Data Source: BioPlex
UPK2
Tbio
Novelty: 0.01066132
p_int: 0.837172437
p_ni: 0.162827563
Data Source: BioPlex
CLEC2D
Tbio
Novelty: 0.02501194
p_int: 0.82770701
p_ni: 0.17229299
Data Source: BioPlex
SYT1
Tbio
Novelty: 0.00176103
Score: 0.89
Data Source: STRINGDB
SNAP25
Tclin
Novelty: 0.00148905
Score: 0.827
Data Source: STRINGDB
SV2B
Tbio
Novelty: 0.02656002
Score: 0.822
Data Source: STRINGDB
SV2C
Tbio
Novelty: 0.03221681
Score: 0.812
Data Source: STRINGDB
SYP
Tbio
Novelty: 0.00021543
Score: 0.799
Data Source: STRINGDB
LAMA5
Tbio
Novelty: 0.02247145
Score: 0.791
Data Source: STRINGDB
Publication Statistics
PubMed Score  789.70

PubMed score by year
PubTator Score  253.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: