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Tbio
PRDM1
PR domain zinc finger protein 1

Protein Classes
Protein Summary
Description
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369089
  • ENSP00000358085
  • ENSG00000057657
  • ENST00000369091
  • ENSP00000358087
  • ENST00000369096
  • ENSP00000358092

Symbol
  • BLIMP1
  • BLIMP1
  • PRDI-BF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
biological process
0.93
gene perturbation
0.93
microRNA
0.93
transcription factor
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 469.11   (req: < 5)
Gene RIFs: 127   (req: <= 3)
Antibodies: 633   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 469.11   (req: >= 5)
Gene RIFs: 127   (req: > 3)
Antibodies: 633   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
53.4
1
1
0
1.1
34.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
53.4
0
1.1
34.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Expression
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Expression
Gene Ontology Terms (36)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (173)
1 – 10 of 173
DPYSL3
Tbio
Family: Enzyme
Novelty: 0.01284077
p_int: 0.998774196
p_ni: 0.00122577
p_wrong: 3.3e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
BMX
Tchem
Family: Kinase
Novelty: 0.00383533
p_int: 0.981743669
p_ni: 0.018256331
Score: 0.24
Data Source: BioPlex,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
p_int: 0.974903452
p_ni: 0.025094795
p_wrong: 0.000001753
Score: 0.265
Data Source: BioPlex,STRINGDB
RRAS
Tbio
Family: Enzyme
Novelty: 0.00786502
p_int: 0.92510317
p_ni: 0.074896807
p_wrong: 2.3e-8
Score: 0.195
Data Source: BioPlex,STRINGDB
UBE4A
Tbio
Novelty: 0.02576018
p_int: 0.800484439
p_ni: 0.198273473
p_wrong: 0.001242089
Score: 0.187
Data Source: BioPlex,STRINGDB
DLG1
Tbio
Novelty: 0.0050926
p_int: 0.797736884
p_ni: 0.202262759
p_wrong: 3.57e-7
Score: 0.216
Data Source: BioPlex,STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.962
Data Source: STRINGDB
PAX5
Tbio
Family: TF
Novelty: 0.0012666
Score: 0.946
Data Source: STRINGDB
IRF4
Tbio
Family: TF
Novelty: 0.00192973
Score: 0.943
Data Source: STRINGDB
BACH2
Tbio
Family: TF
Novelty: 0.00932069
Score: 0.871
Data Source: STRINGDB
Publication Statistics
PubMed Score  469.11

PubMed score by year
PubTator Score  298.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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