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Tbio
HTRA1
Serine protease HTRA1

Protein Summary
Description
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. This ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368984
  • ENSP00000357980
  • ENSG00000166033

Symbol
  • HTRA
  • PRSS11
  • L56
  • HtrA
  • ARMD7
  • ORF480
  • PRSS11
  • CARASIL
  • CADASIL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
PubMedID
0.99
transcription factor perturbation
0.94
biological term
0.92
gene perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 627.31   (req: < 5)
Gene RIFs: 203   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 627.31   (req: >= 5)
Gene RIFs: 203   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
4
0
1.8
99.9
2
2
0
1.9
86.4
disease progression measurement
1
1
0
2.1
75
3
3
3
65.3
systolic blood pressure
1
1
1
45.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.8
99.9
0
1.9
86.4
disease progression measurement
0
2.1
75
3
65.3
systolic blood pressure
1
45.4
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (2)
Degradation of the extracellular matrix (R-HSA-1474228)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Protein-Protein Interactions (95)
1 – 10 of 95
TMEM25
Tdark
Novelty: 0.35505784
p_int: 0.999947389
p_ni: 0.000052256
p_wrong: 3.56e-7
Data Source: BioPlex
SPINK4
Tdark
Family: Enzyme
Novelty: 0.06706505
p_int: 0.999923967
p_ni: 0.00005544
p_wrong: 0.000020593
Score: 0.188
Data Source: BioPlex,STRINGDB
REG4
Tbio
Novelty: 0.01123311
p_int: 0.999918533
p_ni: 0.00004259
p_wrong: 0.000038877
Score: 0.187
Data Source: BioPlex,STRINGDB
AVP
Tbio
Novelty: 0.00016475
p_int: 0.99977256
p_ni: 0.000227369
p_wrong: 7.1e-8
Score: 0.197
Data Source: BioPlex,STRINGDB
DEFB127
Tbio
Novelty: 0.18126756
p_int: 0.999498869
p_ni: 0.000501109
p_wrong: 2.2e-8
Score: 0.157
Data Source: BioPlex,STRINGDB
MGAT4C
Tdark
Family: Enzyme
Novelty: 0.19680806
p_int: 0.999183131
p_ni: 0.000780333
p_wrong: 0.000036536
Data Source: BioPlex
MSMB
Tbio
Novelty: 0.00241546
p_int: 0.998882072
p_ni: 0.000533497
p_wrong: 0.000584431
Data Source: BioPlex
NOG
Tbio
Novelty: 0.0010373
p_int: 0.998611655
p_ni: 0.000669766
p_wrong: 0.000718579
Data Source: BioPlex
C12orf49
Tdark
Novelty: 0.56030929
p_int: 0.998195652
p_ni: 0.001650952
p_wrong: 0.000153397
Score: 0.173
Data Source: BioPlex,STRINGDB
DEFA5
Tbio
Novelty: 0.00863727
p_int: 0.995929102
p_ni: 0.003926221
p_wrong: 0.000144677
Data Source: BioPlex
Publication Statistics
PubMed Score  627.31

PubMed score by year
PubTator Score  327.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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