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Tbio
MMP21
Matrix metalloproteinase-21

Protein Summary
Description
Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028). Cleaves alpha-1-antitrypsin (PubMed:12617721). This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368808
  • ENSP00000357798
  • ENSG00000154485

Symbol
  • HTX7
  • MMP-21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.53
cell line
0.47
cell type or tissue
0.47
metabolite
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.58   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.58   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
5.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 21
VGNC:12369
466230
Macaque
matrix metallopeptidase 21
695797
Mouse
MGI:2664387
214766
Rat
RGD:1309332
293573
Dog
matrix metallopeptidase 21
VGNC:43282
100856605
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 21
Macaque
matrix metallopeptidase 21
Mouse
Rat
Dog
matrix metallopeptidase 21
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N119-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (13)
1 – 10 of 13
CDK13
Tchem
Family: Kinase
Novelty: 0.03084808
Score: 0.9
Data Source: STRINGDB
CDK11A
Tchem
Family: Kinase
Novelty: 0.02312993
Score: 0.748
Data Source: STRINGDB
DBT
Tbio
Family: Enzyme
Novelty: 0.0070589
Score: 0.629
Data Source: STRINGDB
CDK11B
Tchem
Family: Kinase
Novelty: 0.02711308
Score: 0.605
Data Source: STRINGDB
HPX
Tbio
Novelty: 0.00138137
Score: 0.541
Data Source: STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.466
Data Source: STRINGDB
TIMP4
Tbio
Family: Enzyme
Novelty: 0.006231
Score: 0.449
Data Source: STRINGDB
FURIN
Tchem
Family: Enzyme
Novelty: 0.00055079
Score: 0.435
Data Source: STRINGDB
TIMP1
Tbio
Family: Enzyme
Novelty: 0.00020986
Score: 0.427
Data Source: STRINGDB
SMC6
Tbio
Novelty: 0.02450073
Score: 0.422
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.58

PubMed score by year
PubTator Score  17.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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