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Tbio
IVL
Involucrin

Protein Summary
Description
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368764
  • ENSP00000357753
  • ENSG00000163207
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.93
cell type or tissue
0.76
cellular component
0.62
chemical
0.6
gene perturbation
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 630.7   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 701   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 630.7   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 701   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
1.6
1
1
0
1.1
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
1.6
0
1.1
1.6
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
involucrin
VGNC:53230
736637
Mouse
MGI:96626
16447
Rat
RGD:620141
60583
Cow
involucrin
280830
Pig
involucrin
407242
Species
Name
OMA
EggNOG
Inparanoid
Chimp
involucrin
Mouse
Rat
Cow
involucrin
Pig
involucrin
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07476-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (194)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (136)
1 – 10 of 136
KLHL11
Tbio
Novelty: 0.1537041
p_int: 0.99994791
p_ni: 0.00005209
Data Source: BioPlex
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.999940391
p_ni: 0.000059609
Data Source: BioPlex
TEFM
Tbio
Novelty: 0.10836617
p_int: 0.999898573
p_ni: 0.000101427
Data Source: BioPlex
FCF1
Tdark
Novelty: 0.04202976
p_int: 0.999832315
p_ni: 0.000167685
Data Source: BioPlex
PDE4DIP
Tbio
Novelty: 0.03414104
p_int: 0.999828769
p_ni: 0.000171227
p_wrong: 4e-9
Data Source: BioPlex
CCNYL1
Tdark
Novelty: 0.45350824
p_int: 0.999717336
p_ni: 0.000282664
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999373289
p_ni: 0.000626711
Data Source: BioPlex
RBM24
Tbio
Novelty: 0.04562076
p_int: 0.999196487
p_ni: 0.000803506
p_wrong: 7e-9
Data Source: BioPlex
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.99909543
p_ni: 0.00090457
Data Source: BioPlex
HSF2
Tbio
Family: TF
Novelty: 0.06458223
p_int: 0.998784145
p_ni: 0.001215855
Data Source: BioPlex
Publication Statistics
PubMed Score  630.70

PubMed score by year
PubTator Score  211.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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