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Tbio
TRAF3IP2
Adapter protein CIKS

Protein Summary
Description
Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK. This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340026
  • ENSP00000345984
  • ENSG00000056972
  • ENST00000359831
  • ENSP00000352889
  • ENST00000368735
  • ENSP00000357724
  • ENST00000368761
  • ENSP00000357750
  • ENST00000392556
  • ENSP00000376339

Symbol
  • C6orf2
  • C6orf4
  • C6orf5
  • C6orf6
  • ACT1
  • CIKS
  • C6orf2
  • C6orf4
  • C6orf5
  • C6orf6
  • CANDF8
  • PSORS13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.97
kinase perturbation
0.91
gene perturbation
0.83
virus perturbation
0.83
trait
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.11   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.11   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.9
97.4
2
2
0
1.5
94
psoriasis vulgaris
1
1
0
1.4
71.9
C-reactive protein measurement
1
1
1
66.7
intraocular pressure measurement
1
2
2
56.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
97.4
0
1.5
94
psoriasis vulgaris
0
1.4
71.9
C-reactive protein measurement
1
66.7
intraocular pressure measurement
2
56.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TRAF3 interacting protein 2
VGNC:3755
741209
Macaque
TRAF3 interacting protein 2
697530
Mouse
MGI:2143599
103213
Rat
RGD:1593240
361857
Dog
TRAF3 interacting protein 2
VGNC:47766
475031
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TRAF3 interacting protein 2
Macaque
TRAF3 interacting protein 2
Mouse
Rat
Dog
TRAF3 interacting protein 2
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (69)
1 – 10 of 69
QPRT
Tbio
Family: Enzyme
Novelty: 0.00781554
p_int: 0.999964553
p_ni: 9.03e-7
p_wrong: 0.000034544
Score: 0.345
Data Source: BioPlex,STRINGDB
BEX5
Tdark
Novelty: 0.2964824
p_int: 0.999681151
p_ni: 0.000022996
p_wrong: 0.000295853
Data Source: BioPlex
IL17RA
Tclin
Novelty: 0.00416706
Score: 0.835
Data Source: STRINGDB
IL17RB
Tbio
Novelty: 0.01540031
Score: 0.809
Data Source: STRINGDB
IL17RC
Tclin
Novelty: 0.01844832
Score: 0.733
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.733
Data Source: STRINGDB
TRAF5
Tbio
Novelty: 0.01238512
Score: 0.701
Data Source: STRINGDB
IL17A
Tclin
Novelty: 0.00011583
Score: 0.688
Data Source: STRINGDB
FBXL19
Tbio
Novelty: 0.07526966
Score: 0.675
Data Source: STRINGDB
TNIP1
Tbio
Novelty: 0.0147254
Score: 0.669
Data Source: STRINGDB
Publication Statistics
PubMed Score  54.11

PubMed score by year
PubTator Score  149.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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