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Tdark
SPRR2G
Small proline-rich protein 2G

Protein Summary
Description
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368748
  • ENSP00000357737
  • ENSG00000159516
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.51
cellular component
0.39
interacting protein
0.34
tissue
0.34
biological term
0.33


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.88   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 1   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.88   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 1   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (62)
1 – 10 of 62
LCE3D
Tdark
Novelty: 0.20614547
Score: 0.98
Data Source: STRINGDB
LCE3E
Tdark
Novelty: 0.72118892
Score: 0.977
Data Source: STRINGDB
SPRR2E
Tdark
Novelty: 0.78347788
Score: 0.974
Data Source: STRINGDB
LCE2C
Tdark
Novelty: 4.51851552
Score: 0.966
Data Source: STRINGDB
LCE2D
Tdark
Novelty: 1.74927
Score: 0.961
Data Source: STRINGDB
SPRR2D
Tdark
Novelty: 0.28543054
Score: 0.958
Data Source: STRINGDB
LCE2B
Tdark
Novelty: 0.88335558
Score: 0.958
Data Source: STRINGDB
SPRR3
Tbio
Novelty: 0.0241484
Score: 0.954
Data Source: STRINGDB
SPRR2F
Tdark
Novelty: 0.35614731
Score: 0.954
Data Source: STRINGDB
LOR
Tbio
Novelty: 0.0033781
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.88

PubMed score by year
PubTator Score  0.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer