Protein Classes
Protein Summary
S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular ...more
- ENST00000368738
- ENSP00000357727
- ENSG00000163220
- CAGB
- CFAG
- MRP14
- MIF
- NIF
- P14
- CAGB
- CFAG
- CGLB
- L1AG
- LIAG
- MRP14
- 60B8AG
- MAC387
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.99 | ||
biological process | 0.97 | ||
protein complex | 0.97 | ||
small molecule perturbation | 0.97 | ||
molecular function | 0.96 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 904.36 (req: < 5)
Gene RIFs: 363 (req: <= 3)
Antibodies: 1077 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 904.36 (req: >= 5)
Gene RIFs: 363 (req: > 3)
Antibodies: 1077 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 33
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (15)
Reactome (11)
KEGG (1)
PathwayCommons (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 11
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Antimicrobial peptides | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metal sequestration by antimicrobial proteins | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Antimicrobial peptides | ||||
Immune System | ||||
Innate Immune System | ||||
Metal sequestration by antimicrobial proteins | ||||
Neutrophil degranulation | ||||
Gene Ontology Terms (45)
Functions (7)
Components (12)
Processes (26)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (146)
1 – 10 of 146
TTC39A
Novelty: 14
p_int: 0.999999995
p_ni: 5e-9
Data Source: BioPlex
GNPAT
Family: Enzyme
Novelty: 0.0152005
p_int: 0.99950791
p_ni: 0.00049209
Data Source: BioPlex
NME2P1
Family: Kinase
p_int: 0.996911238
p_ni: 0.003088762
Data Source: BioPlex
TTC4
Novelty: 0.01189394
p_int: 0.986578706
p_ni: 0.013421294
Data Source: BioPlex
TBC1D22B
Novelty: 6
p_int: 0.954061316
p_ni: 0.045938684
Data Source: BioPlex
PCYOX1
Family: Enzyme
Novelty: 0.24200876
p_int: 0.937383014
p_ni: 0.062616986
Data Source: BioPlex
PDE4DIP
Novelty: 0.04181178
p_int: 0.930002279
p_ni: 0.069997721
Data Source: BioPlex
PI4KA
Family: Kinase
Novelty: 0.02976615
p_int: 0.929092774
p_ni: 0.070907226
Data Source: BioPlex
SUSD3
Novelty: 1
p_int: 0.897039958
p_ni: 0.102960042
Score: 0.208
Data Source: BioPlex,STRINGDB
DDX19B
Family: Enzyme
Novelty: 0.05099873
p_int: 0.870608509
p_ni: 0.129391491
Data Source: BioPlex
Publication Statistics
PubMed Score 904.36
PubMed score by year
PubTator Score 660.32
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVRKDLQNFLKKENKNEKVIEHIMEDLDTNA
1-70
DKQLSFEEFIMLMARLTWASHEKMHEGDEGPGHHHKPGLGEGTP
70-114
MTCKMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVRKDLQNFLKKENKNEKVIEHIMEDLDTNADKQLSFEEFIMLMARLTWASHEKMHEGDEGPGHHHKPGLGEGTP
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