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Tbio
EBF3
Transcription factor COE3

Protein Summary
Description
Transcriptional activator (PubMed:28017373, PubMed:28017372, PubMed:28017370). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355311
  • ENSP00000347463
  • ENSG00000108001
  • ENST00000368648
  • ENSP00000357637

Symbol
  • COE3
  • COE3
  • OE-2
  • EBF-3
  • HADDS
  • O/E-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
disease perturbation
0.68
microRNA
0.68
PubMedID
0.65
transcription factor
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.33   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.33   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Differentiation of white and brown adipocyte
WikiPathways
Differentiation of white and brown adipocyte
WikiPathways
Differentiation of white and brown adipocyte
WikiPathways
Differentiation of white and brown adipocyte
WikiPathways
Nonalcoholic fatty liver disease
Name
Explore in Pharos
Explore in Source
Differentiation of white and brown adipocyte
Differentiation of white and brown adipocyte
Differentiation of white and brown adipocyte
Differentiation of white and brown adipocyte
Nonalcoholic fatty liver disease
Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (12)
1 – 10 of 12
CPNE2
Tdark
Novelty: 0.24188419
p_int: 0.999937357
p_ni: 0.000062606
p_wrong: 3.7e-8
Score: 0.16
Data Source: BioPlex,STRINGDB
CPNE4
Tbio
Novelty: 0.08077992
p_int: 0.999833534
p_ni: 0.000166466
Score: 0.204
Data Source: BioPlex,STRINGDB
CPNE7
Tbio
Novelty: 0.0748235
p_int: 0.996886618
p_ni: 0.003111898
p_wrong: 0.000001484
Score: 0.231
Data Source: BioPlex,STRINGDB
MT-ND2
Tclin
Family: Enzyme
Novelty: 0.00069255
Score: 0.543
Data Source: STRINGDB
MEN1
Tchem
Novelty: 0.00059287
Score: 0.522
Data Source: STRINGDB
ZNF423
Tbio
Family: TF
Novelty: 0.01718703
Score: 0.513
Data Source: STRINGDB
FBXO31
Tbio
Novelty: 0.23426419
Score: 0.481
Data Source: STRINGDB
SKOR2
Tbio
Novelty: 0.16727156
Score: 0.459
Data Source: STRINGDB
UFD1
Tbio
Novelty: 0.01230296
Score: 0.439
Data Source: STRINGDB
TMTC1
Tbio
Novelty: 0.0063204
Score: 0.437
Data Source: STRINGDB
Publication Statistics
PubMed Score  314.33

PubMed score by year
PubTator Score  67.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer