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Tclin
ROS1
Proto-oncogene tyrosine-protein kinase ROS

Protein Summary
Description
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368508
  • ENSP00000357494
  • ENSG00000047936

Symbol
  • MCF3
  • ROS
  • ROS
  • MCF3
  • c-ros-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
gene perturbation
0.63
biological process
0.55
cell line
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 663.6   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 594   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 663.6   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 594   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 42
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
56
65.2
creatine kinase measurement
1
1
1
27.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
56
65.2
creatine kinase measurement
1
27.2
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (27)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (72)
1 – 10 of 72
OR13G1
Tdark
Family: oGPCR
Novelty: 0.63690138
Score: 0.906
Data Source: STRINGDB
TAS2R50
Tbio
Family: GPCR
Novelty: 0.15747063
Score: 0.905
Data Source: STRINGDB
EML4
Tbio
Novelty: 0.00217772
Score: 0.827
Data Source: STRINGDB
PALLD
Tbio
Novelty: 0.01191944
Score: 0.804
Data Source: STRINGDB
KRAS
Tchem
Family: Enzyme
Novelty: 0.00013856
Score: 0.796
Data Source: STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.792
Data Source: STRINGDB
FRS3
Tbio
Novelty: 0.09479379
Score: 0.766
Data Source: STRINGDB
SLC34A2
Tbio
Family: Transporter
Novelty: 0.00601743
Score: 0.715
Data Source: STRINGDB
PIK3CA
Tclin
Family: Kinase
Novelty: 0.00044273
Score: 0.706
Data Source: STRINGDB
KIF5B
Tbio
Novelty: 0.00515256
Score: 0.703
Data Source: STRINGDB
Publication Statistics
PubMed Score  663.60

PubMed score by year
PubTator Score  339.39

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer