Tbio BGLAP Osteocalcin

Protein Summary

Description

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]

Uniprot Accession IDs

• P02818
• Q5TCK6

Gene Name

• BGLAP

Ensembl ID

• ENST00000368272
• ENSP00000357255
• ENSG00000242252

Symbol

• OC
• BGP
• OCN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.91
disease	0.83
chemical	0.79
phenotype	0.76
biological process	0.7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7694.46   (req: < 5)

Gene RIFs: 193   (req: <= 3)

Antibodies: 906   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7694.46   (req: >= 5)

Gene RIFs: 193   (req: > 3)

Antibodies: 906   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (46)

Reactome (13)

KEGG (1)

PathwayCommons (5)

WikiPathways (27)

Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

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Items per page:

5

1 – 5 of 13

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Reactome	Gamma-carboxylation of protein precursors	10 targets	R-HSA-159740
Reactome	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	11 targets	R-HSA-159854
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Name	Explore in Pharos	Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Gamma-carboxylation of protein precursors	10 targets	R-HSA-159740
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	11 targets	R-HSA-159854
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436

Gene Ontology Terms (40)

Functions (4)

Components (9)

Processes (27)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
hydroxyapatite binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural constituent of bone	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural molecule activity	Non-traceable Author Statement (NAS)	ProtInc

Protein-Protein Interactions (208)

Explore Interacting Targets

1 – 10 of 208

• See Interactions on String-DB

P3H2

Tbio

Family: Enzyme

Novelty: 0.00315791

p_int: 0.999998788

p_ni: 0.000001212

Data Source: BioPlex

SEH1L

Tbio

Novelty: 0.0895265

p_int: 0.99912467

p_ni: 0.00087533

Data Source: BioPlex

POC1A

Tbio

Novelty: 0.04826931

p_int: 0.949737661

p_ni: 0.006387716

p_wrong: 0.043874623

Data Source: BioPlex

HSPA5

Tchem

Novelty: 0.00051387

p_int: 0.924619029

p_ni: 0.075380971

Data Source: BioPlex

NDUFAF7

Tbio

Family: Enzyme

Novelty: 0.26143791

p_int: 0.817982042

p_ni: 0.181750491

p_wrong: 0.000267467

Data Source: BioPlex

GRN

Tbio

Novelty: 0.00096763

p_int: 0.775823501

p_ni: 0.158687199

p_wrong: 0.0654893

Data Source: BioPlex

GGCX

Tclin

Family: Enzyme

Novelty: 0.01163709

Score: 0.975

Data Source: Reactome,STRINGDB

RUNX2

Tbio

Family: TF

Novelty: 0.00035641

Score: 0.971

Data Source: STRINGDB

PTH

Tbio

Novelty: 0.00003793

Score: 0.957

Data Source: STRINGDB

SP7

Tbio

Family: TF

Novelty: 0.00141584

Score: 0.95

Data Source: STRINGDB

Publication Statistics

PubMed Score  7694.46

PubMed score by year

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PubTator Score  6385.92

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MRALTLLALLALAALCIAGQAGAKPSGAESSKGAAFVSKQEGSEVVKRPRRYLYQWLGAPVPYPDPLEPR

1-70

REVCELNPDCDELADHIGFQEAYRRFYGPV

70-100

MRALTLLALLALAALCIAGQAGAKPSGAESSKGAAFVSKQEGSEVVKRPRRYLYQWLGAPVPYPDPLEPRREVCELNPDCDELADHIGFQEAYRRFYGPV

Find similar targets by:

Uniprot Keyword

Biomineralization
Calcium
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disulfide bond
Gamma-carboxyglutamic acid
Metal-binding
Polymorphism
Reference proteome