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Tbio
CD1E
T-cell surface glycoprotein CD1e, membrane-associated

Protein Summary
Description
T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active. This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368154
  • ENSP00000357136
  • ENSG00000158488
  • ENST00000368155
  • ENSP00000357137
  • ENST00000368156
  • ENSP00000357138
  • ENST00000368157
  • ENSP00000357139
  • ENST00000368160
  • ENSP00000357142
  • ENST00000368161
  • ENSP00000357143
  • ENST00000368163
  • ENSP00000357145
  • ENST00000368164
  • ENSP00000357146
  • ENST00000368165
  • ENSP00000357147
  • ENST00000368166
  • ENSP00000357148
  • ENST00000368167
  • ENSP00000357149
  • ENST00000444681
  • ENSP00000402906
  • ENST00000452291
  • ENSP00000416228

Symbol
  • R2
  • CD1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.74
cell type or tissue
0.73
protein domain
0.73
metabolite
0.62
microRNA
0.49


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 555.49   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 555.49   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD1e molecule
VGNC:5018
457421
Macaque
CD1e molecule
718968
Dog
CD1e molecule
VGNC:38936
488610
Horse
CD1e2 molecule
100056437
Cow
CD1e molecule
VGNC:27008
510832
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD1e molecule
Macaque
CD1e molecule
Dog
CD1e molecule
Horse
CD1e2 molecule
Cow
CD1e molecule
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (133)
1 – 10 of 133
FCGRT
Tchem
Novelty: 0.00105713
p_int: 0.999954286
p_ni: 0.000045713
Score: 0.301
Data Source: BioPlex,STRINGDB
SUSD5
Tdark
Novelty: 1.0992718
p_int: 0.999333424
p_ni: 0.000664679
p_wrong: 0.000001897
Data Source: BioPlex
FNDC3A
Tbio
Novelty: 0.04721453
p_int: 0.997920903
p_ni: 0.002079097
Data Source: BioPlex
C1QL1
Tdark
Novelty: 0.11689088
p_int: 0.997490289
p_ni: 0.002509708
p_wrong: 3e-9
Data Source: BioPlex
TMEM59L
Tbio
Novelty: 0.22745646
p_int: 0.996733735
p_ni: 0.003089988
p_wrong: 0.000176276
Data Source: BioPlex
CANX
Tbio
Novelty: 0.00087002
p_int: 0.996536101
p_ni: 0.003463899
Score: 0.18
Data Source: BioPlex,STRINGDB
DPAGT1
Tbio
Family: Enzyme
Novelty: 0.00869839
p_int: 0.994886413
p_ni: 0.000003312
p_wrong: 0.005110275
Score: 0.185
Data Source: BioPlex,STRINGDB
CTAGE5
Tbio
Novelty: 0.04516631
p_int: 0.993574675
p_ni: 0.006425321
p_wrong: 5e-9
Data Source: BioPlex
B2M
Tbio
Novelty: 0.00011248
p_int: 0.990978394
p_ni: 0.009021497
p_wrong: 1.09e-7
Score: 0.795
Data Source: BioPlex,STRINGDB
KCNJ8
Tbio
Family: IC
Novelty: 0.00369886
p_int: 0.98968367
p_ni: 0.010316329
Data Source: BioPlex
Publication Statistics
PubMed Score  555.49

PubMed score by year
PubTator Score  197.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer