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Tbio
SPTA1
Spectrin alpha chain, erythrocytic 1

Protein Summary
Description
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. This gene encodes a member of a family of molecular scaffold proteins that link the plasma membrane to the actin cytoskeleton and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms a component of the erythrocyte plasma membrane. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis-2, pyropoikilocytosis, and spherocytosis, type 3. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368147
  • ENSP00000357129
  • ENSG00000163554
  • ENST00000643759
  • ENSP00000495214

Symbol
  • SPTA
  • EL2
  • HPP
  • HS3
  • SPH3
  • SPTA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.82
gene perturbation
0.72
tissue sample
0.66
phenotype
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.85   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.85   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
5
4
5
96.3
red blood cell distribution width
4
6
8
94.3
mean corpuscular volume
3
6
6
93.6
HbA1c measurement
2
2
2
93.1
reticulocyte count
7
6
20
85
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
5
96.3
red blood cell distribution width
8
94.3
mean corpuscular volume
6
93.6
HbA1c measurement
2
93.1
reticulocyte count
20
85
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Axon guidance
Reactome
COPI-mediated anterograde transport
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Axon guidance
COPI-mediated anterograde transport
Cytokine Signaling in Immune system
Developmental Biology
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (188)
1 – 10 of 188
SPTB
Tbio
Novelty: 0.00467504
Score: 0.992
Data Source: STRINGDB
ANK1
Tbio
Novelty: 0.00225305
Score: 0.977
Data Source: Reactome,STRINGDB
SPTBN2
Tbio
Novelty: 0.01183066
Score: 0.953
Data Source: STRINGDB
SPTBN1
Tbio
Novelty: 0.01490638
Score: 0.95
Data Source: STRINGDB
ANK3
Tbio
Novelty: 0.00429246
Score: 0.947
Data Source: STRINGDB
SPTBN5
Tbio
Novelty: 0.18740061
Score: 0.941
Data Source: STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
Score: 0.938
Data Source: STRINGDB
SPTBN4
Tbio
Novelty: 0.02182293
Score: 0.93
Data Source: STRINGDB
ANK2
Tbio
Novelty: 0.00528351
Score: 0.924
Data Source: Reactome,STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  215.85

PubMed score by year
PubTator Score  263.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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