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Tbio
AIM2
Interferon-inducible protein AIM2

Protein Summary
Description
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368130
  • ENSP00000357112
  • ENSG00000163568

Symbol
  • PYHIN4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
gene perturbation
0.91
cell type or tissue
0.9
virus perturbation
0.64
PubMedID
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.35   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 566   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.35   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 566   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
2
1
3
90.7
1
1
0
1.2
40.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
3
90.7
0
1.2
40.4
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Inflammasomes
Reactome
Innate Immune System
Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Reactome
The AIM2 inflammasome
Name
Explore in Pharos
Explore in Source
Immune System
Inflammasomes
Innate Immune System
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
The AIM2 inflammasome
Gene Ontology Terms (24)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (89)
1 – 10 of 89
CASP1
Tchem
Family: Enzyme
Novelty: 0.00034643
Score: 0.992
Data Source: Reactome,STRINGDB
PYCARD
Tbio
Novelty: 0.00719985
Score: 0.988
Data Source: Reactome,STRINGDB
NLRP3
Tchem
Novelty: 0.00043957
Score: 0.986
Data Source: STRINGDB
NLRP1
Tbio
Novelty: 0.00441627
Score: 0.984
Data Source: STRINGDB
CASP5
Tchem
Family: Enzyme
Novelty: 0.00734661
Score: 0.965
Data Source: STRINGDB
NLRC4
Tbio
Novelty: 0.0032237
Score: 0.964
Data Source: STRINGDB
CARD8
Tbio
Family: Enzyme
Novelty: 0.0146799
Score: 0.942
Data Source: STRINGDB
DHX33
Tbio
Family: Enzyme
Novelty: 0.07473852
Score: 0.937
Data Source: STRINGDB
NLRP9
Tbio
Novelty: 0.075833
Score: 0.93
Data Source: STRINGDB
GSDMD
Tbio
Novelty: 0.00500354
Score: 0.898
Data Source: STRINGDB
Publication Statistics
PubMed Score  307.35

PubMed score by year
PubTator Score  179.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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