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Tbio
VANGL2
Vang-like protein 2

Protein Summary
Description
Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368061
  • ENSP00000357040
  • ENSG00000162738

Symbol
  • KIAA1215
  • STB1
  • LPP1
  • LTAP
  • STB1
  • STBM
  • STBM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
cellular component
0.75
microRNA
0.74
cell type or tissue
0.63
transcription factor perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.26   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.26   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
55.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
55.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
VANGL planar cell polarity protein 2
720239
Mouse
MGI:2135272
93840
Rat
RGD:1309442
289229
Horse
VANGL planar cell polarity protein 2
VGNC:24881
100053765
Cow
VANGL planar cell polarity protein 2
VGNC:36762
520544
Species
Name
OMA
EggNOG
Inparanoid
Macaque
VANGL planar cell polarity protein 2
Mouse
Rat
Horse
VANGL planar cell polarity protein 2
Cow
VANGL planar cell polarity protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9ULK5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Asymmetric localization of PCP proteins (R-HSA-4608870)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asymmetric localization of PCP proteins
Reactome
Beta-catenin independent WNT signaling
Reactome
PCP/CE pathway
Reactome
Signal Transduction
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Asymmetric localization of PCP proteins
Beta-catenin independent WNT signaling
PCP/CE pathway
Signal Transduction
Signaling by WNT
Gene Ontology Terms (47)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (155)
1 – 10 of 155
GPR156
Tdark
Family: GPCR
Novelty: 0.39183023
p_int: 0.999995783
p_ni: 0.000004217
Data Source: BioPlex
ANKRD36B
Tdark
Novelty: 2.44907149
p_int: 0.999971365
p_ni: 0.000028634
Data Source: BioPlex
HDGFL2
Tbio
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.999914409
p_ni: 0.000085591
Data Source: BioPlex
DVL3
Tbio
Novelty: 0.01606014
p_int: 0.999901145
p_ni: 0.000098855
Score: 0.966
Data Source: BioPlex,STRINGDB
EPB41L1
Tbio
Novelty: 0.02937451
p_int: 0.999883599
p_ni: 0.000116296
p_wrong: 1.05e-7
Data Source: BioPlex
PNN
Tbio
Novelty: 0.01395394
p_int: 0.999644439
p_ni: 0.000355561
Data Source: BioPlex
DVL2
Tbio
Novelty: 0.00833084
p_int: 0.999286752
p_ni: 0.000713247
p_wrong: 1e-9
Score: 0.971
Data Source: BioPlex,STRINGDB
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.9873001
p_ni: 0.012699899
Data Source: BioPlex
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.98635813
p_ni: 0.013641869
Score: 0.265
Data Source: BioPlex,STRINGDB
EPB41L3
Tbio
Novelty: 0.00915217
p_int: 0.981916596
p_ni: 0.018083275
p_wrong: 1.29e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  203.26

PubMed score by year
PubTator Score  69.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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