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Tbio
SH2D1B
SH2 domain-containing protein 1B

Protein Summary
Description
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367929
  • ENSP00000356906
  • ENSG00000198574

Symbol
  • EAT2
  • EAT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.7
virus perturbation
0.55
kinase perturbation
0.54
cell type or tissue
0.52
tissue
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.17   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.17   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (60)
1 – 10 of 60
SIRPA
Tbio
Family: Enzyme
Novelty: 0.0021102
p_int: 0.999999501
p_ni: 4.98e-7
p_wrong: 2e-9
Data Source: BioPlex
ABLIM1
Tbio
Novelty: 0.05511373
p_int: 0.999997977
p_ni: 0.000002024
Data Source: BioPlex
ROBO1
Tbio
Novelty: 0.00494884
p_int: 0.91155529
p_ni: 0.001585281
p_wrong: 0.086859429
Data Source: BioPlex
SLAMF6
Tbio
Novelty: 0.01459284
Score: 0.975
Data Source: Reactome,STRINGDB
CD244
Tbio
Novelty: 0.01137579
Score: 0.968
Data Source: STRINGDB
SLAMF7
Tclin
Novelty: 0.01014396
Score: 0.912
Data Source: STRINGDB
SLAMF1
Tbio
Novelty: 0.00112892
Score: 0.85
Data Source: STRINGDB
CD84
Tbio
Novelty: 0.02811289
Score: 0.849
Data Source: STRINGDB
LY9
Tbio
Novelty: 0.01892831
Score: 0.812
Data Source: STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
Score: 0.708
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.17

PubMed score by year
PubTator Score  29.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer